Gabe Luke M, Malo Joshua, Knox Kenneth S
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona College of Medicine - Tucson, 1501 North Campbell Avenue, Tucson, AZ 85724, USA.
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona College of Medicine - Tucson, 1501 North Campbell Avenue, Tucson, AZ 85724, USA.
Clin Chest Med. 2017 Sep;38(3):417-433. doi: 10.1016/j.ccm.2017.04.005. Epub 2017 Jun 3.
Coccidioidomycosis is a leading cause of community-acquired pneumonia within its traditional endemic zone in the Southwestern United States and portions of Mexico and Central and South America. Its incidence has increased dramatically within the endemic region; its presence outside of the region, facilitated by a mobile society, is also now substantial. Although only a fraction of the incident disease progresses beyond subclinical illness, this proportion is large in absolute terms and causes substantial disease burden. Diagnosis often depends on serologic interpretation. Treatment has been revolutionized by azole therapy. Controversy remains regarding the decision to treat in less severe disease.
球孢子菌病是美国西南部、墨西哥部分地区以及中美洲和南美洲传统流行区内社区获得性肺炎的主要病因。在流行区域内其发病率急剧上升；在流动社会的推动下，该疾病在区域外的存在也已相当普遍。尽管只有一小部分发病病例会发展到亚临床疾病以上阶段，但从绝对数量来看，这一比例很大，会造成相当大的疾病负担。诊断通常依赖于血清学解读。唑类疗法使治疗发生了变革。对于病情较轻的病例是否进行治疗，仍存在争议。
