Aronis John M, Millett Nicholas E, Wagner Michael M, Tsui Fuchiang, Ye Ye, Ferraro Jeffrey P, Haug Peter J, Gesteland Per H, Cooper Gregory F
Real-time Outbreak and Disease Surveillance Laboratory, Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
Real-time Outbreak and Disease Surveillance Laboratory, Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
J Biomed Inform. 2017 Sep;73:171-181. doi: 10.1016/j.jbi.2017.08.003. Epub 2017 Aug 7.
Outbreaks of infectious diseases such as influenza are a significant threat to human health. Because there are different strains of influenza which can cause independent outbreaks, and influenza can affect demographic groups at different rates and times, there is a need to recognize and characterize multiple outbreaks of influenza. This paper describes a Bayesian system that uses data from emergency department patient care reports to create epidemiological models of overlapping outbreaks of influenza. Clinical findings are extracted from patient care reports using natural language processing. These findings are analyzed by a case detection system to create disease likelihoods that are passed to a multiple outbreak detection system. We evaluated the system using real and simulated outbreaks. The results show that this approach can recognize and characterize overlapping outbreaks of influenza. We describe several extensions that appear promising.
流感等传染病的爆发对人类健康构成重大威胁。由于存在不同的流感毒株,它们可引发独立的疫情爆发,且流感会以不同的速率和时间影响不同人群,因此有必要识别和描述多次流感疫情爆发的特征。本文介绍了一种贝叶斯系统,该系统利用急诊科患者护理报告中的数据来创建流感重叠疫情爆发的流行病学模型。使用自然语言处理从患者护理报告中提取临床发现。这些发现由病例检测系统进行分析,以生成疾病可能性,并将其传递给多重疫情爆发检测系统。我们使用真实和模拟疫情爆发对该系统进行了评估。结果表明,这种方法能够识别和描述流感的重叠疫情爆发。我们还描述了几个看起来很有前景的扩展。