Bansal Parveen, Malik Manzoor Ahmad, Das Satya N, Kaur Jasbir
University Centre of Excellence in Research, Baba Farid University of Health Sciences, Punjab, India.
Cancer Diagnostic and Research Centre, Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
Gulf J Oncolog. 2017 May;1(24):10-14.
Natural products with medicinal value are gradually gaining importance in clinical research due to their well-known property of no side effects as compared to drugs. Tinospora cordifolia (Guduchi) has been used for centuries in Ayurvedic system of medicine for treating various ailments including cancer. In present study, we found that the Tinospora cordifolia extracts (TCE) induced inhibition of proliferation of KB cells was associated with arrest of G0/G1-phase of cell cycle. The effectiveness of TCE in checking the growth of KB cells without altering the growth of normal peripheral blood mononuclear cells (PBMC) indicates that Tinospora cordifolia has differential effect on normal and malignant cells hence, it may have therapeutic potential in cancer.
与药物相比，具有药用价值的天然产物因其众所周知的无副作用特性，在临床研究中逐渐变得重要起来。印度防己（Tinospora cordifolia，古杜奇）在阿育吠陀医学体系中用于治疗包括癌症在内的各种疾病已有数百年历史。在本研究中，我们发现印度防己提取物（TCE）诱导KB细胞增殖抑制与细胞周期G0/G1期停滞有关。TCE在不改变正常外周血单个核细胞（PBMC）生长的情况下抑制KB细胞生长的有效性表明，印度防己对正常细胞和恶性细胞具有不同作用，因此，它在癌症治疗中可能具有潜在的治疗价值。
