Dhama Kuldeep, Sachan Swati, Khandia Rekha, Munjal Ashok, Iqbal Hafiz M N, Latheef Shyma K, Karthik Kumaragurubaran, Samad Hari A, Tiwari Ruchi, Dadar Maryam
Division of Pathology, ICARIndian Veterinary Research Institute (IVRI), Izatnagar, Bareilly-243 122, Uttar Pradesh. India.
Immunology Section, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh. India.
Recent Pat Endocr Metab Immune Drug Discov. 2017;10(2):96-111. doi: 10.2174/1872214811666170301105101.
Plants have been known as an integral part of traditional medicine because of their phytoconstituents with their miraculous substances. Tinospora cordifolia (Guduchi/ Giloy) is one such plant having pharmacological functions and medicinal values due to its several constituents such as terpenes, glycosides, alkaloids, steroids and flavonoids. Thus, it has been rightly mentioned in old texts as "Amrita".
The objective of the present review is to extend the current knowledge, importance and beneficial pharmacological applications of guduchi in humans for safeguarding various health issues.
We extensively reviewed, analyzed and compiled salient information from the published literature available in PubMed and other scientific databases.
The present review describes medicinal applications of T. cordifolia in countering various disorders and usages as anti-oxidant, anti-hyperglycemic, antihyperlipidemic, hepatoprotective, cardiovascular protective, neuroprotective, osteoprotective, radioprotective, anti-anxiety, adaptogenic agent, analgesic, anti-inflammatory, antipyretic, a thrombolytic agent, anti-diarrheal, anti-ulcer, anti-microbial and anti-cancer agent. The plant is also a source of micronutrients viz. copper, calcium, phosphorus, iron, zinc and manganese. A special focus has been made on its health benefits in treating endocrine and metabolic disorders and its potential as an immune booster. Several patents have been filed and granted to inventions encompassing T. cordifolia as a major component of therapeutics for ameliorating metabolic, endocrinal and several other ailments, aiding in the betterment of human life expectancy.
The information presented would be beneficial for researchers, medical professionals and pharmaceutical companies to design and develop effective medicines, drugs and healthical products exploiting the multiple as well as specific modes of actions of T. cordifolia, and also help in promoting and popularizing this rich herb having promising potentials to prevent and treat various ailments.
由于植物含有具有神奇功效的植物成分，它们一直是传统医学不可或缺的一部分。心叶青牛胆（古杜奇/吉洛伊）就是这样一种植物，因其含有萜类、糖苷、生物碱、甾体和黄酮类等多种成分而具有药理功能和药用价值。因此，它在古籍中被恰当地称为“甘露”。
本综述的目的是扩展关于古杜奇对人类各种健康问题的保护作用的现有知识、重要性和有益的药理应用。
我们广泛查阅、分析和整理了来自PubMed及其他科学数据库中已发表文献的重要信息。
本综述描述了心叶青牛胆在对抗各种疾病方面的药用应用，以及作为抗氧化剂、抗高血糖、抗高血脂、保肝、心血管保护、神经保护、骨保护、辐射保护、抗焦虑、适应原、镇痛、抗炎、解热、溶栓、止泻、抗溃疡、抗菌和抗癌剂的用途。该植物也是微量营养素的来源，即铜、钙、磷、铁、锌和锰。特别关注了其在治疗内分泌和代谢紊乱方面的健康益处及其作为免疫增强剂的潜力。已经提交并授予了多项专利，这些发明涵盖将心叶青牛胆作为治疗代谢、内分泌和其他多种疾病的主要成分，有助于提高人类预期寿命。
所提供的信息将有助于研究人员、医学专业人员和制药公司设计和开发有效的药物、药品和保健品，利用心叶青牛胆的多种以及特定作用方式，也有助于推广和普及这种具有预防和治疗各种疾病潜力的丰富草药。
