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DNA 三角及其在减数分裂学习中的应用。

The DNA Triangle and Its Application to Learning Meiosis.

作者信息

Wright L Kate, Catavero Christina M, Newman Dina L

机构信息

Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester, NY 14623

Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester, NY 14623.

出版信息

CBE Life Sci Educ. 2017 Fall;16(3). doi: 10.1187/cbe.17-03-0046.

DOI:10.1187/cbe.17-03-0046
PMID:28798212
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5589430/
Abstract

Although instruction on meiosis is repeated many times during the undergraduate curriculum, many students show poor comprehension even as upper-level biology majors. We propose that the difficulty lies in the complexity of understanding DNA, which we explain through a new model, the The DNA triangle integrates three distinct scales at which one can think about DNA: , , and Through analysis of interview and survey data from biology faculty and students through the lens of the DNA triangle, we illustrate important differences in how novices and experts are able to explain the concepts of , , and Similarly, analysis of passages from 16 different biology textbooks shows a large divide between introductory and advanced material, with introductory books omitting explanations of meiosis-linked concepts at the level of DNA. Finally, backed by textbook findings and feedback from biology experts, we show that the DNA triangle can be applied to teaching and learning meiosis. By applying the DNA triangle to topics on meiosis we present a new framework for educators and researchers that ties concepts of ploidy, homology, and mechanism of homologous pairing to knowledge about DNA on the chromosomal, molecular, and informational levels.

摘要

尽管减数分裂的教学在本科课程中重复了很多次,但许多学生,即使是高年级的生物学专业学生,理解能力也很差。我们认为困难在于理解DNA的复杂性,我们通过一个新模型——DNA三角形来解释这一点。DNA三角形整合了三种不同的尺度,人们可以从这些尺度来思考DNA:染色体尺度、分子尺度和信息尺度。通过从DNA三角形的角度分析生物学教师和学生的访谈及调查数据,我们说明了新手和专家在解释倍性、同源性和同源配对机制等概念时的重要差异。同样,对16本不同生物学教科书段落的分析表明,入门材料和高级材料之间存在很大差距,入门书籍在DNA的染色体水平上省略了与减数分裂相关概念的解释。最后,在教科书研究结果和生物学专家反馈的支持下,我们表明DNA三角形可应用于减数分裂的教学和学习。通过将DNA三角形应用于减数分裂主题,我们为教育工作者和研究人员提供了一个新框架,将倍性、同源性和同源配对机制的概念与染色体、分子和信息层面的DNA知识联系起来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59bd/5589430/8a7bf6dac0dc/ar50fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59bd/5589430/6e2846278bf2/ar50fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59bd/5589430/e69d14eba80e/ar50fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59bd/5589430/4a1f4e5b2cc4/ar50fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59bd/5589430/8a7bf6dac0dc/ar50fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59bd/5589430/6e2846278bf2/ar50fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59bd/5589430/e69d14eba80e/ar50fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59bd/5589430/4a1f4e5b2cc4/ar50fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59bd/5589430/8a7bf6dac0dc/ar50fig4.jpg

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本文引用的文献

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Beyond the Central Dogma: Model-Based Learning of How Genes Determine Phenotypes.超越中心法则:基于模型的基因如何决定表型的学习。
CBE Life Sci Educ. 2016 Spring;15(1):ar4. doi: 10.1187/cbe.15-04-0105.
3
Development of a meiosis concept inventory.减数分裂概念量表的开发。
描述学生对 DNA 非编码区域中突变的影响的想法。
CBE Life Sci Educ. 2019 Jun;18(2):ar18. doi: 10.1187/cbe.18-09-0173.
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Students fail to transfer knowledge of chromosome structure to topics pertaining to cell division.学生无法将染色体结构的知识转移到与细胞分裂相关的主题上。
CBE Life Sci Educ. 2012 Winter;11(4):425-36. doi: 10.1187/cbe.12-01-0003.
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Using the Genetics Concept Assessment to document persistent conceptual difficulties in undergraduate genetics courses.运用遗传学概念评估来记录本科遗传学课程中持续存在的概念性困难。
Genetics. 2012 May;191(1):21-32. doi: 10.1534/genetics.111.137810. Epub 2012 Feb 23.
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An interactive modeling lesson increases students' understanding of ploidy during meiosis.一堂互动式建模课程增强了学生对减数分裂过程中染色体倍性的理解。
Biochem Mol Biol Educ. 2011 Sep-Oct;39(5):344-51. doi: 10.1002/bmb.20523.
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