Department of Ophthalmology, Medical University of Graz, Auenbruggerplatz 4, 8036, Graz, Austria.
Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Sci Rep. 2017 Aug 10;7(1):7829. doi: 10.1038/s41598-017-08295-1.
Although intraocular pressure is the main the risk factor for the development of glaucoma, other risk factors such as vascular dysfunction might play an additional pathogenic role. Hypertriglyceridemia, which may lead to vascular dysfunction, has been implicated in the development of glaucoma. The objective of this meta-analysis was to investigate the association of triglyceride levels with the risk of glaucoma in case-control studies. Seventeen case-control studies were included investigating the difference in triglyceride levels in patients with glaucoma (N = 1 391) compared to subjects without glaucoma (N = 25 575). In random effects meta-analysis, the pooled mean triglyceride level across all studies and patients with and without glaucoma was 132.9 mg/dL (95%CI: 124.0-141.7). Patients with glaucoma had significantly higher mean triglyceride levels than patients without glaucoma (absolute difference = 14.2 mg/dL, 95%CI: 5.8-22.5, p < 0.0001). A considerable amount of heterogeneity of included studies was observed (I = 66.2%, heterogeneity χ = 47.4 on 16 degrees of freedom, p < 0.0001). In conclusion, this meta-analysis of case-control studies found that patients with glaucoma had higher mean triglyceride levels than patients without glaucoma. This finding is consistent with the concept that hypertriglyceridemia represents an additional risk factor for glaucoma. Whether this association is causal and/or might be modified by glaucoma medications remains to be investigated.
尽管眼压是青光眼发展的主要危险因素，但其他危险因素，如血管功能障碍，可能发挥额外的致病作用。可能导致血管功能障碍的高甘油三酯血症与青光眼的发展有关。本荟萃分析的目的是研究甘油三酯水平与病例对照研究中青光眼风险的相关性。共纳入了 17 项病例对照研究，这些研究调查了青光眼患者（N=1391）与无青光眼患者（N=25575）之间甘油三酯水平的差异。在随机效应荟萃分析中，所有研究和有青光眼及无青光眼患者的甘油三酯平均水平为 132.9mg/dL（95%CI：124.0-141.7）。与无青光眼患者相比，青光眼患者的甘油三酯平均水平显著升高（绝对差值=14.2mg/dL，95%CI：5.8-22.5，p<0.0001）。纳入研究的异质性较大（I=66.2%，异质性 χ=47.4，自由度为 16，p<0.0001）。总之，本病例对照研究的荟萃分析发现，青光眼患者的甘油三酯平均水平高于无青光眼患者。这一发现与高甘油三酯血症代表青光眼的另一个危险因素的概念一致。这种关联是否是因果关系，以及/或者是否可能被青光眼药物所改变，仍有待研究。
