Jotereau F, Heuze F, Salomon-Vie V, Gascan H
J Immunol. 1987 Feb 15;138(4):1026-30.
The entry and differentiation of lymphoid precursor cells (LPC) in grafted mouse fetal thymuses and the emigration of explants thymocytes has been followed in a system in which donor and host lymphocytes could be distinguished on the basis of Thy-1 expression. It appears that LPC that invade the fetal mouse thymus between 10 and 13 days rapidly differentiate into Thy-1 positive thymocytes, giving rise to all of the lymphoid populations of both cortical and medullary locations until approximately the end of the first week after birth. Lymphoid precursor cells that enter the fetal thymus after 13 days of fetal life only differentiate into Thy-1 positive lymphocytes 6 or 7 days after birth, when they give rise to a second generation of thymocytes that grows exponentially and completely replaces the first generation in approximately 8 days. All cells leaving the thymus during the first 2 wk of life appear to be derived from the first wave of precursors.
在一个能够根据Thy-1表达区分供体和宿主淋巴细胞的系统中，对移植的小鼠胎儿胸腺中淋巴前体细胞（LPC）的进入和分化以及外植体胸腺细胞的迁出进行了追踪。似乎在10至13天之间侵入胎儿小鼠胸腺的LPC迅速分化为Thy-1阳性胸腺细胞，直至出生后第一周结束时产生皮质和髓质部位的所有淋巴细胞群。在胎儿期13天后进入胎儿胸腺的淋巴前体细胞仅在出生后6或7天分化为Thy-1阳性淋巴细胞，此时它们产生第二代胸腺细胞，该细胞呈指数增长并在大约8天内完全取代第一代。出生后前2周内离开胸腺的所有细胞似乎都来自第一波前体细胞。
