Kirby Institute for Infection and Immunity, University of New South Wales Australia, Sydney, New South Wales, Australia.
Department of Microbiology and Immunology, Cornell University, Ithaca, NY, USA.
Nat Rev Immunol. 2020 Aug;20(8):499-506. doi: 10.1038/s41577-020-0332-3. Epub 2020 Jun 3.
We are just beginning to understand the diversity of the peripheral T cell compartment, which arises from the specialization of different T cell subsets and the plasticity of individual naive T cells to adopt different fates. Although the progeny of a single T cell can differentiate into many phenotypes following infection, individual T cells are biased towards particular phenotypes. These biases are typically ascribed to random factors that occur during and after antigenic stimulation. However, the T cell compartment does not remain static with age, and shifting immune challenges during ontogeny give rise to T cells with distinct functional properties. Here, we argue that the developmental history of naive T cells creates a 'hidden layer' of diversity that persists into adulthood. Insight into this diversity can provide a new perspective on immunity and immunotherapy across the lifespan.
我们才刚刚开始了解外周 T 细胞区室的多样性，这种多样性源于不同 T 细胞亚群的专业化以及单个初始 T 细胞向不同命运转变的可塑性。虽然单个 T 细胞的后代在感染后可以分化为多种表型，但单个 T 细胞偏向于特定的表型。这些偏向通常归因于抗原刺激过程中和之后发生的随机因素。然而，随着年龄的增长，T 细胞区室并不会保持静止，在个体发生过程中不断变化的免疫挑战会产生具有独特功能特性的 T 细胞。在这里，我们认为初始 T 细胞的发育历史会产生一个持续到成年期的“隐藏层”多样性。深入了解这种多样性可以为整个生命周期的免疫和免疫治疗提供新的视角。
