Holodick Nichol E, Rodríguez-Zhurbenko Nely, Hernández Ana María
Department of Biomedical Sciences, Center for Immunobiology, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, United States.
Natural Antibodies Group, Tumor Immunology Division, Center of Molecular Immunology, Havana, Cuba.
Front Immunol. 2017 Jul 26;8:872. doi: 10.3389/fimmu.2017.00872. eCollection 2017.
The traditional definition of natural antibodies (NAbs) states that these antibodies are present prior to the body encountering cognate antigen, providing a first line of defense against infection thereby, allowing time for a specific antibody response to be mounted. The literature has a seemingly common definition of NAbs; however, as our knowledge of antibodies and B cells is refined, re-evaluation of the common definition of Nabs may be required. Defining Nabs becomes important as the function of NAb production is used to define B cell subsets (1) and as these important molecules are shown to play numerous roles in the immune system (Figure 1). Herein, we aim to briefly summarize our current knowledge of NAbs in the context of initiating a discussion within the field of how such an important and multifaceted group of molecules should be defined.
天然抗体（NAbs）的传统定义指出，这些抗体在机体遇到同源抗原之前就已存在，从而提供抵御感染的第一道防线，为特异性抗体反应的启动争取时间。文献中对NAbs有一个看似普遍的定义；然而，随着我们对抗体和B细胞的认识不断细化，可能需要重新评估NAbs的普遍定义。由于NAb产生的功能被用于定义B细胞亚群（1），且这些重要分子在免疫系统中发挥着众多作用（图1），因此对NAbs进行定义变得很重要。在此，我们旨在简要总结我们目前对NAbs的认识，以引发该领域关于如何定义这一重要且多面的分子群体的讨论。
