Elluru Sri-Ramulu, Vani Janakiraman, Delignat Sandrine, Bloch Marie-Françoise, Lacroix-Desmazes Sébastien, Kazatchkine Michel D, Kaveri Srini V, Bayry Jagadeesh
Centre de Recherche des Cordeliers, Université Pierre et Marie Curie - Paris 6, UMR S 872, Paris, F-75006, France.
Autoimmun Rev. 2008 Jun;7(6):487-90. doi: 10.1016/j.autrev.2008.04.014. Epub 2008 May 7.
Dendritic cells (DCs) are professional antigen-presenting cells, which have a central role in the initiation of primary immune responses and in maintaining immune tolerance. The functions of DCs can be regulated both by environmental signals as well as signals delivered by endogenous molecules. Recently we have examined regulation of human DCs by B cells via natural IgG antibodies. Natural antibodies (NAbs) are defined as antibodies that circulate in normal individuals in the absence of deliberate immunization or microbial aggression. We demonstrate that the differentiation of DCs is severely impaired in primary immunodeficient patients such as X-linked agammaglobulinemia (XLA) and common variable immunodeficiency (CVID) at least in part due to the deficiency of circulating NAbs. Further, we show that NAbs are able to restore normal phenotypes of DCs from patients with XLA and CVID. Our results suggest that B cells promote bystander DC development through NAbs and the interaction between NAbs and DCs may play a role in steady-state migration of DCs.
树突状细胞（DCs）是专职抗原呈递细胞，在启动原发性免疫反应和维持免疫耐受方面发挥着核心作用。DCs的功能可由环境信号以及内源性分子传递的信号进行调节。最近，我们研究了B细胞通过天然IgG抗体对人DCs的调节作用。天然抗体（NAbs）被定义为在未进行刻意免疫或无微生物侵袭的正常个体中循环的抗体。我们证明，在原发性免疫缺陷患者中，如X连锁无丙种球蛋白血症（XLA）和常见可变免疫缺陷（CVID），DCs的分化至少部分由于循环NAbs的缺乏而严重受损。此外，我们表明NAbs能够恢复XLA和CVID患者DCs的正常表型。我们的结果表明，B细胞通过NAbs促进旁观者DC的发育，并且NAbs与DCs之间的相互作用可能在DCs的稳态迁移中发挥作用。
