中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值在克罗恩病中的诊断价值
Diagnostic Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Crohn's Disease.
作者信息
Feng Jue-Rong, Qiu Xiao, Wang Fan, Chen Peng-Fei, Gao Qian, Peng Ya-Nan, Lin Xue, Liu Qing, Liu Jing, Zhao Qiu, Li Jin
机构信息
Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Hubei Clinical Center & Key Laboratory of Intestinal & Colorectal Diseases, Wuhan, China.
出版信息
Gastroenterol Res Pract. 2017;2017:3526460. doi: 10.1155/2017/3526460. Epub 2017 Jul 17.
The aim of this study is to investigate the diagnostic efficacy of neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-monocyte ratio (NMR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in patients with Crohn's disease (CD) and non-CD controls. These ratios were all derived from complete blood counts. Two hundred and six participants including CD inpatients and non-CD controls were retrospectively enrolled. We found statistically higher NLR and PLR and lower LMR in CD patients than in non-CD controls (all < 0.01). However, NMR was not different between the two groups ( = 0.18). In addition, NLR, PLR, and LMR were associated with CRP and ESR. Optimal cutoffs for NLR and PLR were 2.72 (sensitivity: 68.3%, specificity: 75.9%, and overall accuracy: 70.1%) and 132.88 (sensitivity: 76.7%, specificity: 84.8%, and overall accuracy: 80.8%), respectively. In conclusion, the NLR and PLR might be effective, readily available, and low-cost biomarkers for differentiating CD patients from non-CD controls.
本研究旨在探讨中性粒细胞与淋巴细胞比值（NLR）、中性粒细胞与单核细胞比值（NMR）、淋巴细胞与单核细胞比值（LMR）及血小板与淋巴细胞比值（PLR）在克罗恩病（CD）患者及非CD对照中的诊断效能。这些比值均来自全血细胞计数。回顾性纳入了206名参与者，包括CD住院患者及非CD对照。我们发现，CD患者的NLR和PLR在统计学上高于非CD对照，而LMR低于非CD对照（均P<0.01）。然而，两组间NMR无差异（P = 0.18）。此外，NLR、PLR和LMR与CRP及ESR相关。NLR和PLR的最佳截断值分别为2.72（敏感性：68.3%，特异性：75.9%，总体准确率：70.1%）和132.88（敏感性：76.7%，特异性：84.8%，总体准确率：80.8%）。总之，NLR和PLR可能是区分CD患者与非CD对照的有效、易于获得且低成本的生物标志物。
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