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C-反应蛋白/白蛋白比值和白细胞介素-6 与溃疡性结肠炎患者的疾病活动度相关。

C-reactive protein/albumin ratio and IL-6 are associated with disease activity in patients with ulcerative colitis.

机构信息

Department of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine), Nanjing, China.

出版信息

J Clin Lab Anal. 2023 Feb;37(3):e24843. doi: 10.1002/jcla.24843. Epub 2023 Feb 1.

DOI:10.1002/jcla.24843
PMID:36725336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9978084/
Abstract

BACKGROUND

Cytokines are key mediators of the inflammation in ulcerative colitis (UC); there are inconsistent data on cytokines profile in patients with UC. C-reactive protein/albumin ratio (CRP/ALB) has also been found as an inflammatory indicator. However, the role of CRP/ALB in UC remains unclear. We aimed to evaluate the CRP/ALB ratio and cytokines profile in patients with UC. We further explore the association between CRP/ALB and inflammatory markers, such as erythrocyte sedimentation rate (ESR), fecal calprotectin (FC) and cytokines.

METHODS

One hundred thirty UC patients and 65 controls were included in the study. Clinical and laboratory findings were retrospectively reviewed; differences in variables between two groups were examined using the Mann-Whitney U-test. The association between CRP/ALB, cytokines, and clinical parameters was determined by Spearman's correlation test.

RESULTS

CRP/ALB levels were significantly elevated in active UC patients. The optimal cutoff level of the CRP/ALB was 0.083. The patients with active UC had a median interleukin-6 (IL-6) level of 7.715 pg/ml (interquartile ranges, IQR 3.475-14.63), which was significantly higher than those in remission (2.95 pg/ml, IQR 2.17-5.44) (p < 0.001). Positive correlations between CRP/ALB and inflammatory markers were also observed.

CONCLUSIONS

Our results suggest that CRP/ALB and IL-6 could be potential biomarkers for assessment of clinical activity in Chinese patients with UC.

摘要

背景

细胞因子是溃疡性结肠炎（UC）炎症的关键介质；UC 患者的细胞因子谱数据不一致。C 反应蛋白/白蛋白比值（CRP/ALB）也被发现是一种炎症指标。然而，CRP/ALB 在 UC 中的作用仍不清楚。我们旨在评估 UC 患者的 CRP/ALB 比值和细胞因子谱。我们进一步探讨 CRP/ALB 与炎症标志物（如红细胞沉降率（ESR）、粪便钙卫蛋白（FC）和细胞因子）之间的关系。

方法

本研究纳入了 130 例 UC 患者和 65 名对照。回顾性分析临床和实验室检查结果；采用 Mann-Whitney U 检验比较两组间变量差异。采用 Spearman 相关检验确定 CRP/ALB、细胞因子与临床参数之间的相关性。

结果

活动期 UC 患者 CRP/ALB 水平显著升高。CRP/ALB 的最佳截断值为 0.083。活动期 UC 患者的白细胞介素-6（IL-6）水平中位数为 7.715pg/ml（四分位间距，IQR 3.475-14.63），明显高于缓解期（2.95pg/ml，IQR 2.17-5.44）（p<0.001）。CRP/ALB 与炎症标志物之间也存在正相关。

结论

我们的研究结果表明，CRP/ALB 和 IL-6 可能是评估中国 UC 患者临床活动的潜在生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f189/9978084/0770c94068ef/JCLA-37-e24843-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f189/9978084/0770c94068ef/JCLA-37-e24843-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f189/9978084/0770c94068ef/JCLA-37-e24843-g001.jpg

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