Gubbala Kumar, Laios Alexandros, Madhuri Thulumuru Kavitha, Pathiraja Pubudu, Haldar Krishnayan, Kehoe Sean
Gynaecologic Oncology Unit, Churchill Hospital, Oxford University Hospitals, Oxford, UK.
Department of Gynaecological Oncology, The Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK.
Int J Surg Oncol. 2017;2017:2962450. doi: 10.1155/2017/2962450. Epub 2017 Jul 17.
In the UK, more than 3,200 new cases of cervical cancer are diagnosed each year. Early stage cervical cancer (IA2-IB1) treatment comprises central surgery mainly in the form of radical hysterectomy or fertility sparing surgery including trachelectomy as well as systematic pelvic lymphadenectomy to detect metastases and adjust treatment accordingly. Given the variation in determining the lymph node (LN) status, a major prognosticator, we reviewed the current UK practice of LN assessment in women undergoing surgery for early cervical cancer. A 7-question, web-based survey, screened by the BGCS committee, was circulated amongst BGCS members. The overall response rate was 51%. Only 12.5% of the respondents routinely performed frozen section examination (FSE); the main reasons for not doing FSE were the pressure on theatre time (54.5%) and the lack of available facilities (48.5%). When positive pelvic nodal disease was detected, in 21 out of 50 (42%) the planned radical hysterectomy (RH) was aborted. More than 70% of the respondents routinely performed RH without any prior resort to pelvic lymphadenectomy. Pretreatment surgical para-aortic LN assessment was performed by 20% of the respondents. The survey confirms the diversity of the UK practice patterns in the surgical treatment of early cervical cancer.
在英国,每年有超过3200例宫颈癌新发病例被确诊。早期宫颈癌(IA2 - IB1)的治疗主要包括以根治性子宫切除术或保留生育功能手术(包括宫颈切除术)为主的中心性手术,以及系统性盆腔淋巴结清扫术,以检测转移情况并据此调整治疗方案。鉴于作为主要预后指标的淋巴结(LN)状态判定存在差异,我们回顾了英国目前对早期宫颈癌手术患者进行LN评估的实践情况。一项由英国妇科癌症学会(BGCS)委员会筛选的、基于网络的7个问题的调查问卷在BGCS成员中进行了分发。总体回复率为51%。只有12.5%的受访者常规进行冰冻切片检查(FSE);不进行FSE的主要原因是手术时间紧张(54.5%)和缺乏可用设备(48.5%)。当检测到盆腔淋巴结阳性病变时,50例中有21例(42%)取消了计划中的根治性子宫切除术(RH)。超过70%的受访者常规进行RH,而没有事先进行盆腔淋巴结清扫术。20%的受访者进行了术前手术性腹主动脉旁LN评估。该调查证实了英国早期宫颈癌手术治疗实践模式的多样性。