功能衰退与肌萎缩侧索硬化症（ALS）患者的绝望感相关。
Functional Decline is Associated with Hopelessness in Amyotrophic Lateral Sclerosis (ALS).
作者信息
Paganoni Sabrina, McDonnell Erin, Schoenfeld David, Yu Hong, Deng Jing, Atassi Hamza, Sherman Alexander, Yerramilli-Rao Padmaja, Cudkowicz Merit, Atassi Nazem
机构信息
Department of Neurology, Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital; Harvard Medical School, USA.
Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, USA.
出版信息
J Neurol Neurophysiol. 2017 Apr;8(2). doi: 10.4172/2155-9562.1000423. Epub 2017 Apr 29.
OBJECTIVE
To determine the relationships between hopelessness, depression, quality of life, and disease progression in ALS.
METHODS
Hopelessness and depression were assessed prospectively in a cohort of people with ALS using the Beck Hopelessness scale (BHS) and the ALS Depression Inventory (ADI-12), respectively. ALS Specific Quality of Life and measures of functional status (ALSFRS-R and forced vital capacity) were collected. Associations between changes in psychological health and functional scores were calculated using Spearman correlation coefficients.
RESULTS
Twenty-five people with ALS had at least 2 visits and were followed for a mean of 11 (± 6) months. People with hopelessness and depression reported worse quality of life (p<0.01 for both associations). Decline in function between any two visits measured by ALSFRS-R (p<0.01) and FVC (p=0.02) correlated with increased hopelessness, but not depression.
CONCLUSION
This study highlights the importance of monitoring hopelessness in ALS, particularly in patients with faster functional decline.
目的
确定肌萎缩侧索硬化症（ALS）患者中绝望感、抑郁、生活质量和疾病进展之间的关系。
方法
分别使用贝克绝望量表（BHS）和ALS抑郁量表（ADI - 12）对一组ALS患者进行前瞻性绝望感和抑郁评估。收集ALS特定生活质量和功能状态指标（ALSFRS - R和用力肺活量）。使用斯皮尔曼相关系数计算心理健康变化与功能评分之间的关联。
结果
25例ALS患者至少有2次就诊，并平均随访11（±6）个月。有绝望感和抑郁的患者报告生活质量较差（两种关联均p<0.01）。用ALSFRS - R（p<0.01）和FVC（p = 0.02）测量的任意两次就诊之间的功能下降与绝望感增加相关，但与抑郁无关。
结论
本研究强调了在ALS中监测绝望感的重要性，特别是在功能下降较快的患者中。
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