Kondo Seiji, Kawashima Jiro, Kobata Katsumi, Ohgawara Toshihiro, Tanaka Shiho, Nabeshima Kazuki, Kikuta Toshihiro
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Department of Pathology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Diagn Cytopathol. 2018 Jan;46(1):63-66. doi: 10.1002/dc.23792. Epub 2017 Aug 11.
Pemphigus vulgaris (PV) is a chronic autoimmune bullous disease characterized by the formation of suprabasal cleavage and acantholysis. As this disease almost always affects the oral mucosa, conventional cytological smears of oral lesions can be used for the initial diagnosis of PV. We report two cases of PV that were initially diagnosed based on cytological smears of an oral sample. As atypical squamous cells were present even in the liquid-based cytological (LBC) smears of the oral lesion in these two cases, this ultimately led to the misinterpretation of squamous cell carcinoma. These findings demonstrate that cytological mimicry of oral PV can occur in malignant cases when there is an absence of appropriate clinical information.
寻常型天疱疮（PV）是一种慢性自身免疫性大疱性疾病，其特征为基底上裂隙形成和棘层松解。由于该疾病几乎总是累及口腔黏膜，口腔病变的传统细胞学涂片可用于PV的初步诊断。我们报告了两例最初根据口腔样本的细胞学涂片诊断为PV的病例。由于这两例病例中，即使在口腔病变的液基细胞学（LBC）涂片中也存在非典型鳞状细胞，这最终导致了鳞状细胞癌的误诊。这些发现表明，当缺乏适当的临床信息时，口腔PV在恶性病例中可能会出现细胞学上的模仿。
