Akamatsu Setsu, Kodama Shoji, Himeji Yukari, Ikuta Naomi, Shimagaki Nikako
Division of Cytology, Shibata Comprehensive Health Care Service Center, Shibata, Japan.
Acta Cytol. 2012;56(4):370-4. doi: 10.1159/000337641. Epub 2012 Jul 25.
To clarify the performance of liquid-based cytology (LBC) and conventional methods of preparing cervical specimens for cytological screening.
We studied 236,511 patients who participated in a population-based cervical cancer screening program conducted in the Niigata prefecture between 2005 and 2008. The percentage of unsatisfactory specimens and the disease detection rate were compared between specimens prepared by LBC and conventional methods.
(1) The LBC method demonstrated a significantly lower percentage of unsatisfactory specimens than the conventional method (1.38 and 11.45%, respectively; p < 0.01). (2) Among the initial women, tumor lesions were detected in 0.57% of those examined with the LBC method, which was significantly higher than the positivity rate of those examined with the conventional method (0.25%; p < 0.05). Among the women with repeat screening, disease was detected in 0.08% of those examined with LBC twice, which was significantly lower than the positivity rates for those examined with the conventional method followed by the LBC method (0.11%) or the conventional method twice (0.16%; p < 0.05).
The LBC method is significantly more useful than the conventional method in terms of the low adequacy rate and the high detection rate of cancer in cervical cancer screening in a localized area in Japan.
阐明液基细胞学检查（LBC）及传统方法制备宫颈标本用于细胞学筛查的性能。
我们研究了2005年至2008年期间参与新潟县基于人群的宫颈癌筛查项目的236,511名患者。比较了LBC方法和传统方法制备的标本中不满意标本的百分比及疾病检出率。
（1）LBC方法不满意标本的百分比显著低于传统方法（分别为1.38%和11.45%；p<0.01）。（2）在初次检查的女性中，LBC检查方法的受检者中有0.57%检测到肿瘤病变，显著高于传统方法受检者的阳性率（0.25%；p<0.05）。在重复筛查的女性中，LBC检查两次的受检者中有0.08%检测到疾病，显著低于传统方法后接LBC方法（0.11%）或传统方法检查两次（0.16%）的阳性率（p<0.05）。
在日本局部地区的宫颈癌筛查中，就低标本不合格率和高癌症检出率而言，LBC方法比传统方法明显更有用。
