From the State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research (N.S., Q.B., T.Z.), Center for Collaboration and Innovation in Brain and Learning Sciences (N.S., Q.B., T.Z.), and Beijing Key Laboratory of Brain Imaging and Connectomics (N.S., Q.B., T.Z.), Beijing Normal University, Beijing, P. R. China; Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing 100053, P. R. China (X.W., Y.H.); Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, P. R. China (X.W., Y.H.); National Clinical Research Center for Geriatric Disorders, Beijing, P. R. China (Y.H.); and PKU Care Rehabilitation Hospital, Beijing, P. R. China (Y.H.).
Radiology. 2018 Jan;286(1):229-238. doi: 10.1148/radiol.2017162696. Epub 2017 Aug 11.
Purpose To determine whether individuals with subjective cognitive decline (SCD), which is defined by memory complaints with normal performance at objective neuropsychologic examinations, exhibit disruptions of white matter (WM) connectivity and topologic alterations of the brain structural connectome. Materials and Methods Diffusion-tensor magnetic resonance imaging and graph theory approaches were used to investigate the topologic organization of the brain structural connectome in 36 participants with SCD (21 women: mean age, 62.0 years ± 8.6 [standard deviation]; age range, 42-76 years; 15 men: mean age, 65.5 years ± 8.9; age range, 51-80 years) and 51 age-, sex-, and years of education-matched healthy control participants (33 women: mean age, 63.7 years ± 8.8; age range, 46-83 years; 18 men: mean age, 59.4 years ± 9.3; age range, 43-75 years). Individual WM networks were constructed for each participant, and the network properties between two groups were compared with a linear regression model. Results Graph theory analyses revealed that the participants with SCD had less global efficiency (P = .001) and local efficiency (P = .008) compared with the healthy control participants. Lower regional efficiency was mainly distributed in the bilateral prefrontal regions and left thalamus (P < .05, corrected). Furthermore, a disrupted subnetwork was observed that consisted of widespread anatomic connections (P < .05, corrected), which has the potential to discriminate individuals with SCD from control participants. Moreover, similar hub distributions and less connection strength between the hub regions (P = .023) were found in SCD. Importantly, diminished strength of the rich-club and local connections was correlated with the impaired memory performance in patients with SCD (rich-club connection: r = 0.43, P = .011; local connection: r = 0.36, P = .037). Conclusion This study demonstrated disrupted topologic efficiency of the brain's structural connectome in participants with SCD and provided potential connectome-based biomarkers for the early detection of cognitive impairment in elderly individuals. RSNA, 2017 Online supplemental material is available for this article.
确定是否存在主观认知下降（SCD）个体存在脑白质（WM）连接中断和脑结构连接组拓扑改变。SCD 是指以客观神经心理检查正常表现为特征的记忆主诉。
采用弥散张量磁共振成像和图论方法，研究 36 例 SCD 患者（21 例女性：平均年龄 62.0 岁±8.6[标准差]；年龄范围 42-76 岁；15 例男性：平均年龄 65.5 岁±8.9；年龄范围 51-80 岁）和 51 名年龄、性别和受教育年限匹配的健康对照者（33 名女性：平均年龄 63.7 岁±8.8；年龄范围 46-83 岁；18 名男性：平均年龄 59.4 岁±9.3；年龄范围 43-75 岁）的脑结构连接组拓扑组织。为每位参与者构建 WM 网络，并通过线性回归模型比较两组之间的网络特性。
图论分析显示，与健康对照组相比，SCD 患者的全局效率（P =.001）和局部效率（P =.008）较低。较低的区域效率主要分布在双侧前额叶和左侧丘脑（P <.05，校正）。此外，观察到一个破坏的子网，该子网由广泛的解剖连接组成（P <.05，校正），这有可能将 SCD 患者与对照组区分开来。此外，在 SCD 患者中还发现了类似的枢纽分布和枢纽区域之间的连接强度较低（P =.023）。重要的是，SCD 患者的丰富俱乐部连接和局部连接强度的降低与记忆表现受损相关（丰富俱乐部连接：r = 0.43，P =.011；局部连接：r = 0.36，P =.037）。
本研究显示 SCD 患者脑结构连接组拓扑效率降低，并为老年个体认知障碍的早期检测提供了潜在的连接组生物标志物。
RSNA，2017 在线补充材料可用于本文。
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