Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Center for Epidemiology and Community Medicine, Stockholm County Council, Stockholm, Sweden.
Psychiatry Res. 2017 Nov;257:322-326. doi: 10.1016/j.psychres.2017.07.071. Epub 2017 Jul 31.
There is evidence supporting an association between the serotonin-transporter-linked polymorphic region (5-HTTLPR) and the Five Factor Model (FFM) of human personality. 5-HTTLPR has also been found to interact with stressful life events to increase risk of psychopathology. In the present study, by taking into account stressful life events in the form of childhood adversity, we examined the association between 5-HTTLPR and FFM traits using an adult Swedish cohort (N = 3112). We found that 5-HTTLPR was significantly associated with openness (to experience). Specifically, homozygote carriers of the short allele had lower levels of openness compared to carriers of the long allele. In addition, childhood adversity was found to influence openness. These findings support a previously reported association of 5-HTTLPR with openness in a younger cohort and may provide insights into the neurobiological basis of human personality.
有证据支持 5-羟色胺转运体相关多态性区域（5-HTTLPR）与人类人格的五因素模型（FFM）之间存在关联。5-HTTLPR 也被发现与生活应激事件相互作用，增加精神病理学的风险。在本研究中，我们通过考虑以儿童逆境形式的生活应激事件，使用瑞典成人队列（N=3112）来检查 5-HTTLPR 与 FFM 特质之间的关联。我们发现 5-HTTLPR 与开放性（体验）显著相关。具体而言，短等位基因纯合子携带者的开放性水平低于长等位基因携带者。此外，儿童逆境被发现会影响开放性。这些发现支持了先前报道的 5-HTTLPR 与年轻队列开放性之间的关联，并且可能为人类个性的神经生物学基础提供了一些见解。
