Abu Raya Maison, Ogunyemi Adedoyin O, Broder Jake, Carstensen Veronica Rojas, Illanes-Manrique Maryenela, Rankin Katherine P
Global Brain Health Institute, University of California, San Francisco, San Francisco, CA, United States.
Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco School of Medicine, San Francisco, CA, United States.
Front Neurol. 2023 Aug 14;14:1235345. doi: 10.3389/fneur.2023.1235345. eCollection 2023.
Openness is a multifaceted behavioral disposition that encompasses personal, interpersonal, and cultural dimensions. It has been suggested that the interindividual variability in openness as a personality trait is influenced by various environmental and genetic factors, as well as differences in brain functional and structural connectivity patterns along with their various associated cognitive processes. Alterations in degree of openness have been linked to several aspects of health and disease, being impacted by both physical and mental health, substance use, and neurologic conditions. This review aims to explore the current state of knowledge describing the neurobiological basis of openness and how individual differences in openness can manifest in brain health and disease.
开放性是一种多方面的行为倾向，涵盖个人、人际和文化维度。有人提出，作为一种人格特质，开放性的个体间差异受多种环境和遗传因素影响，也受大脑功能和结构连接模式及其各种相关认知过程差异的影响。开放性程度的改变与健康和疾病的多个方面相关，受到身心健康、物质使用和神经疾病的影响。本综述旨在探讨描述开放性神经生物学基础的当前知识状态，以及开放性的个体差异如何在大脑健康和疾病中表现出来。
