Liang Qi, Lei Xin-Jun, Li Hong-Bing, Yin Yang-Rong, Ren Jie, Fan Li-Hong, Huang Xin, Yuan Zu-Yi
Department of Cardiology, First Affiliate Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, China. E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2017 Aug 20;37(8):1022-1027. doi: 10.3969/j.issn.1673-4254.2017.08.04.
To investigate clinical implications of changes in red cell distribution width (RDW) and mean platelet volume (MPV) in patients with acute myocardial infarction.
A total of 127 patients (90 men and 37 women) were enrolled in this analysis, including 66 with acute myocardial infarction (AMI) and 61 with unstable angina (UA). The patients' baseline demographic and clinical data were compared between the two groups including age, hypertension, diabetes, smoking, BMI, blood biochemical profiles, cardiac functions and platelet and red blood cell parameters. The patients were further divided into subgroups according to the RDW 50% cumulative frequency, and the MPV, P-LCR, hsCRP, NT-proBNP, RBC, Dimer and MCV were compared. The correlations between platelet and erythrocyte test results were evaluated in both the AMI and UA patients. Regression analysis was performed to identify the factors affecting the RDW in the AMI group and a regression model was established.
The platelet and red blood cell test results, P-LCR, MPV, and RDW differed significantly between AMI and UA groups (P<0.01 or 0.05). Correlation analysis showed a significant positive correlation between RDW and MPV in AMI group (r=0.34, P<0.01). Between the subgroups with different RDW 50% cumulative frequencies, MPV, P-LCR, hsCRP, D-Dimer, and NT-proBNP all differed significantly (P<0.05 or 0.01). In AMI group, with RDW as the dependent variable, we established a multivariate regression model of RDW=0.19MPV+10.83.
RDW and MPV are closely correlated in patients with AMI. In multiple regression analysis, MPV can explain the changes in RDW in patients with AMI.
探讨急性心肌梗死患者红细胞分布宽度（RDW）和平均血小板体积（MPV）变化的临床意义。
本分析共纳入127例患者（90例男性和37例女性），其中急性心肌梗死（AMI）患者66例，不稳定型心绞痛（UA）患者61例。比较两组患者的基线人口统计学和临床数据，包括年龄、高血压、糖尿病、吸烟、体重指数、血液生化指标、心功能以及血小板和红细胞参数。根据RDW 50%累积频率将患者进一步分为亚组，比较MPV、血小板大细胞比率（P-LCR）、超敏C反应蛋白（hsCRP）、N末端脑钠肽前体（NT-proBNP）、红细胞（RBC）、D-二聚体和平均红细胞体积（MCV）。评估AMI和UA患者血小板和红细胞检测结果之间的相关性。进行回归分析以确定影响AMI组RDW的因素并建立回归模型。
AMI组和UA组的血小板和红细胞检测结果、P-LCR、MPV和RDW差异有统计学意义（P<0.01或0.05）。相关性分析显示AMI组RDW与MPV呈显著正相关（r=0.34，P<0.01）。在不同RDW 50%累积频率的亚组之间，MPV、P-LCR、hsCRP、D-二聚体和NT-proBNP均有显著差异（P<0.05或0.01）。在AMI组中，以RDW为因变量，建立了RDW=0.19MPV+10.83的多元回归模型。
AMI患者的RDW和MPV密切相关。在多元回归分析中，MPV可解释AMI患者RDW的变化。
