Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
Sci Rep. 2017 Aug 11;7(1):7951. doi: 10.1038/s41598-017-07811-7.
We investigated the association of the newly established lipid accumulation product (LAP) and visceral adiposity index (VAI) with intracranial atherosclerotic stenosis (ICAS) in middle-aged and elderly Chinese. From June 2012 to January 2013, consecutive patients ≥40 years of age who underwent cerebral vascular imaging for various medical reasons were enrolled in this study. Multivariate logistic regression models were used to evaluate the correlation of VAI and LAP with the risk of ICAS. In total, 845 patients were included in the study. The prevalence of ICAS gradually increased in females and in all patients with advancing tertiles of VAI or LAP. After adjusting for potential risks, both the VAI and LAP were related to ICAS in females [VAI: odds ratio (OR) = 3.25, 95% confidence interval (95%CI) = 1.17-9.03, P = 0.024; LAP: OR = 4.11, 95%CI = 1.39-12.12, P = 0.011; tertiles 3 vs. 1]. The sensitivity, specificity, and positive predictive value (PPV) were 74.7%, 45.5%, and 84.4% for VAI (cut-off: 1.71) and 79.3%, 40.5%, and 84.1% for LAP (cut-off: 23.99). The same relationships in males were not significant. Both VAI and LAP were closely associated with an increased risk of ICAS in middle-aged and elderly Chinese females.
我们研究了新建立的脂类蓄积产物（LAP）和内脏脂肪指数（VAI）与中老年中国人颅内动脉粥样硬化狭窄（ICAS）的相关性。从 2012 年 6 月至 2013 年 1 月，连续纳入因各种医疗原因接受脑血管成像检查的年龄≥40 岁的患者。多变量逻辑回归模型用于评估 VAI 和 LAP 与 ICAS 风险的相关性。共纳入 845 例患者。女性和所有 VAI 或 LAP 三分位升高的患者中，ICAS 的患病率逐渐升高。调整潜在风险后，VAI 和 LAP 与女性 ICAS 均相关[VAI：比值比（OR）=3.25，95%置信区间（95%CI）=1.17-9.03，P=0.024；LAP：OR=4.11，95%CI=1.39-12.12，P=0.011；三分位 3 与 1]。VAI（截断值：1.71）的灵敏度、特异度和阳性预测值（PPV）分别为 74.7%、45.5%和 84.4%，LAP（截断值：23.99）分别为 79.3%、40.5%和 84.1%。男性的这些关系不显著。VAI 和 LAP 均与中老年中国女性 ICAS 风险增加密切相关。
