CYP2C19基因多态性及非遗传因素对东亚冠心病患者氯吡格雷血小板抑制作用的影响 - Suppr

The effect of CYP2C19 genetic polymorphism and non-genetic factors on clopidogrel platelets inhibition in East Asian coronary artery disease patients.

作者信息

Amin Arwa M, Sheau Chin Lim, Mohamed Noor Dzul Azri, Mostafa Hamza, Abdul Kader Muhamad Ali S K, Kah Hay Yuen, Ibrahim Baharudin

机构信息

School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.

出版信息

Thromb Res. 2017 Oct;158:22-24. doi: 10.1016/j.thromres.2017.07.032. Epub 2017 Aug 1.

DOI:10.1016/j.thromres.2017.07.032

PMID:28802144

Abstract

摘要

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The effect of CYP2C19 genetic polymorphism and non-genetic factors on clopidogrel platelets inhibition in East Asian coronary artery disease patients.CYP2C19基因多态性及非遗传因素对东亚冠心病患者氯吡格雷血小板抑制作用的影响

Thromb Res. 2017 Oct;158:22-24. doi: 10.1016/j.thromres.2017.07.032. Epub 2017 Aug 1.

Impact of CYP3A5 polymorphism on platelet reactivity at percutaneous coronary intervention and after 9 months of aspirin and clopidogrel therapy in Japanese patients with coronary artery disease.CYP3A5基因多态性对日本冠心病患者经皮冠状动脉介入治疗时及阿司匹林和氯吡格雷治疗9个月后的血小板反应性的影响。

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Decreased platelet responsiveness to clopidogrel correlates with CYP2C19 and PON1 polymorphisms in atherosclerotic patients.动脉粥样硬化患者中，血小板对氯吡格雷的反应性降低与CYP2C19和PON1基因多态性相关。

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Effects of cytochrome P450 2C19 and paraoxonase 1 polymorphisms on antiplatelet response to clopidogrel therapy in patients with coronary artery disease.细胞色素P450 2C19和对氧磷酶1基因多态性对冠心病患者氯吡格雷治疗抗血小板反应的影响。

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CYP2C19*2 and Other Allelic Variants Affecting Platelet Response to Clopidogrel Tested by Thrombelastography in Patients with Acute Coronary Syndrome.通过血栓弹力图检测急性冠状动脉综合征患者中影响血小板对氯吡格雷反应的CYP2C19*2及其他等位基因变体

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Genetic and non-genetic factors responsible for antiplatelet effects of clopidogrel in Japanese patients undergoing coronary stent implantation: an algorithm to predict on-clopidogrel platelet reactivity.导致日本经皮冠状动脉介入治疗（PCI）术后患者氯吡格雷抗血小板作用的遗传和非遗传因素：预测氯吡格雷抵抗血小板反应的算法。

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Comparison of the antiplatelet effect of clopidogrel hydrogenosulfate and clopidogrel besylate in patients with stable coronary artery disease.硫酸氢氯吡格雷与氯吡格雷硫酸氢盐对稳定型冠状动脉疾病患者抗血小板作用的比较。

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Genetic determinants of high on-treatment platelet reactivity in clopidogrel treated Chinese patients.氯吡格雷治疗的中国患者中治疗时血小板高反应性的遗传决定因素。

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The Impact of CYP2C19 Genotype on the Platelet Reactivity Index (PRI) among Chronic Coronary Syndromes (CCS) Patients Undergoing Percutaneous Coronary Intervention (PCI): Affectability of Rapid Genetic Testing.CYP2C19基因分型对接受经皮冠状动脉介入治疗（PCI）的慢性冠状动脉综合征（CCS）患者血小板反应指数（PRI）的影响：快速基因检测的敏感性

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The effect of CYP2C19 genetic polymorphism and non-genetic factors on clopidogrel platelets inhibition in East Asian coronary artery disease patients.

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