胆脂瘤作为颞骨朗格汉斯细胞组织细胞增多症的一种并发症：一项全国性横断面分析。
Cholesteatoma as a complication of Langerhans Cell Histiocytosis of the temporal bone: A nationwide cross-sectional analysis.
作者信息
Simmonds Jonathan C, Vecchiotti Mark
机构信息
Department of Pediatric Otolaryngology, Floating Hospital for Children at Tufts Medical Center, 800 Washington St. Boston, MA 02111, United States.
出版信息
Int J Pediatr Otorhinolaryngol. 2017 Sep;100:66-70. doi: 10.1016/j.ijporl.2017.06.022. Epub 2017 Jun 22.
OBJECTIVE
To determine if patients with Langerhans Cell Histiocytosis (LCH) of the temporal bone have a higher risk of developing cholesteatoma.
METHODS
Review of literature and cross-sectional weighted analysis of patients under 19 with a diagnosis of LCH from the National Inpatient Sample (NIS) and Kids' Inpatient Database (KID) from 2000 to 2013. ICD-9 codes and demographics were analyzed; pairwise comparisons and multivariate analyses were performed.
RESULTS
Only seven cases of cholesteatoma after the treatment for LCH of the temporal bone have been documented in the literature. No significant association between cholesteatoma and LCH was seen (OR 0.747 [0.149-3.751]). Patients with LCH did have a higher incidence of chronic otitis media, chronic otitis externa, chronic sinusitis, hearing loss, and otitis media with effusion.
CONCLUSION
Our results show that patients with Langerhans Cell Histiocytosis do not appear to have a higher risk of developing cholesteatoma. However they are more likely to be diagnosed with chronic otitis externa which should be differentiated from cholesteatoma or recurrence of LCH.
目的
确定颞骨朗格汉斯细胞组织细胞增多症（LCH）患者发生胆脂瘤的风险是否更高。
方法
回顾2000年至2013年来自国家住院样本（NIS）和儿童住院数据库（KID）中诊断为LCH的19岁以下患者的文献并进行横断面加权分析。分析国际疾病分类第九版（ICD - 9）编码和人口统计学数据；进行成对比较和多变量分析。
结果
文献中仅记录了7例颞骨LCH治疗后发生胆脂瘤的病例。未发现胆脂瘤与LCH之间存在显著关联（比值比0.747 [0.149 - 3.751]）。LCH患者慢性中耳炎、慢性外耳道炎、慢性鼻窦炎、听力损失和中耳积液的发生率确实更高。
结论
我们的结果表明，朗格汉斯细胞组织细胞增多症患者发生胆脂瘤的风险似乎并不更高。然而，他们更有可能被诊断为慢性外耳道炎，应与胆脂瘤或LCH复发相鉴别。
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