Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College, London, UK.
Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College, London, UK.
Curr Opin Pharmacol. 2017 Oct;36:29-33. doi: 10.1016/j.coph.2017.07.006. Epub 2017 Aug 10.
Insulin deficiency and impaired glucose homeostasis are hallmarks of type 1 diabetes. Since the discovery of insulin, pharmacological and clinical developments have endeavoured to replicate its endogenous pharmacokinetics (PK) and pharmacodynamics (PD). Closed loop insulin delivery systems operate as an artificial pancreas by making automated insulin dose adjustments based on real time continuous glucose monitoring. The increasing adoption of continuous insulin pump therapy and evolving technological advances have seen significant progress in the development of closed loop insulin delivery systems. This article reviews the current landscape of closed loop insulin delivery systems and pharmacological advances that could overcome current barriers.
胰岛素缺乏和葡萄糖稳态受损是 1 型糖尿病的特征。自从胰岛素被发现以来，药理学和临床发展一直致力于复制其内源性药代动力学（PK）和药效动力学（PD）。闭环胰岛素输送系统通过根据实时连续血糖监测自动调整胰岛素剂量来模拟胰腺的功能，以此作为人工胰腺运行。随着连续胰岛素泵治疗的日益普及和技术的不断进步，闭环胰岛素输送系统的开发取得了重大进展。本文综述了闭环胰岛素输送系统的现状和可以克服当前障碍的药理学进展。
