Debecker A, Henon P, Lepers M, Eisenmann J C, Selva J
Nouv Rev Fr Hematol (1978). 1986;28(5):287-92.
The level of circulating myeloid progenitor cells (CFU-G), considered to be a good index of the quantity of circulating hemopoietic stem cells, was measured in the peripheral blood of 5 patients with acute leukemia as they entered first remission. High levels of circulating CFU-G were found in 4 of these 5 patients, depending on the intensity and the number of courses of induction chemotherapy. Repeated cytaphereses were done on 3 of these patients in order to collect and to cryopreserve circulating stem cells, to be used later for autologous transplantation. We propose a model which calculates the number of cytaphereses sufficient to obtain a level of 10(5) CFU-G/kg of weight, considered necessary to achieve a good hemopoietic reconstitution after transplantation.
循环髓系祖细胞（CFU-G）水平被认为是循环造血干细胞数量的良好指标，在5例急性白血病患者首次进入缓解期时，对其外周血中的该指标进行了检测。这5例患者中有4例循环CFU-G水平较高，这取决于诱导化疗的强度和疗程数。对其中3例患者进行了反复的血细胞分离术，以收集和冷冻保存循环干细胞，供以后进行自体移植使用。我们提出了一个模型，该模型可计算出足以获得10⁵CFU-G/千克体重水平的血细胞分离术次数，这一水平被认为是移植后实现良好造血重建所必需的。
