The First Clinical College, Liaoning University of Traditional Chinese Medicine (TCM), Chongshan East Road No.72, Shenyang, Liaoning, 110032, China.
Department of Endocrine, Affiliated Hospital, Liaoning University of TCM, Beiling Street No.33, Shenyang, Liaoning, 110032, China.
Biol Trace Elem Res. 2018 May;183(1):114-122. doi: 10.1007/s12011-017-1115-y. Epub 2017 Aug 12.
Iodine-rich herbs such as seaweed, kelp, and sea tangle were widely used to treat various types of goiter with good effect and without any adverse side effects in China. When compared with potassium iodate (PI), iodine-rich herbs had a positive effect on the recovery of goiter resulting from iodine deficiency without any obvious harmful effects. In NOD.H-2 mice, an autoimmune thyroiditis-prone model, iodine excess can increase infiltration of lymphocytes and structural damage of the thyroid follicles, hence resulting in thyroiditis. Until now, there has been little research on the comparative effects of PI and iodine-rich herbs on thyroid in an autoimmune thyroiditis-prone model. This study was designed to compare the different effects of iodine-rich herbs and PI on the thyroid gland in iodine-deficient NOD.H-2 mice. Excessive intake of PI cause oxidative injury in the thyroid gland and increase the risk of autoimmune thyroiditis, while iodine-rich herbs cause less oxidative injury, significantly enhancing antioxidant capacity, and inhibit the high differentiation of Th17 cells in the thyroid glands of NOD.H-2 mice.
在中国，富碘草药（如海藻、昆布和海草）被广泛用于治疗各种类型的甲状腺肿，疗效好，且无任何不良反应。与碘酸钾 (PI) 相比，富碘草药对碘缺乏引起的甲状腺肿的恢复有积极作用，且无明显的有害作用。在自身免疫性甲状腺炎易感模型 NOD.H-2 小鼠中，碘过量会增加淋巴细胞浸润和甲状腺滤泡的结构损伤，从而导致甲状腺炎。到目前为止，关于 PI 和富碘草药对自身免疫性甲状腺炎易感模型甲状腺的比较效果的研究很少。本研究旨在比较富碘草药和 PI 对碘缺乏 NOD.H-2 小鼠甲状腺的不同影响。过量摄入 PI 会导致甲状腺氧化损伤，增加自身免疫性甲状腺炎的风险，而富碘草药引起的氧化损伤较小，显著增强抗氧化能力，并抑制 NOD.H-2 小鼠甲状腺中 Th17 细胞的高分化。
