Diogo Camila Cardoso, Costa Luís Maltez da, Pereira José Eduardo, Filipe Vítor, Couto Pedro Alexandre, Magalhães Luís G, Geuna Stefano, Armada-da-Silva Paulo A, Maurício Ana Colette, Varejão Artur Severo
Department of Veterinary Sciences, University of Trás-os-Montes e Alto Douro, UTAD, Quinta de Prados, 5000-801 Vila Real, Portugal.
Department of Veterinary Sciences, University of Trás-os-Montes e Alto Douro, UTAD, Quinta de Prados, 5000-801 Vila Real, Portugal; CECAV, Centre for Animal Sciences and Veterinary Studies, University of Trás-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal.
Behav Brain Res. 2017 Sep 29;335:132-135. doi: 10.1016/j.bbr.2017.08.016. Epub 2017 Aug 10.
Of all the detrimental effects of spinal cord injury (SCI), one of the most devastating is the disruption of the ability to perform functional movement. Very little is known on the recovery of hindlimb joint kinematics after clinically-relevant contusive thoracic lesion in experimental animal models. A new functional assessment instrument, the dynamic feet distance (DFD) was used to describe the distance between the two feet throughout the gait cycle in normal and affected rodents. The purpose of this investigation was the evaluation and characterization of the DFD during treadmill locomotion in normal and T9 contusion injured rats, using three-dimensional (3D) instrumented gait analysis. Despite that normal and injured rats showed a similar pattern in the fifth metatarsal head joints distance excursion, we found a significantly wider distance between the feet during the entire gait cycle following spinal injury. This is the first study to quantify the distance between the two feet, throughout the gait cycle, and the biomechanical adjustments made between limbs in laboratory rodents after nervous system injury.
在脊髓损伤（SCI）的所有有害影响中，最具破坏性的影响之一是进行功能性运动的能力受到破坏。在实验动物模型中，对于临床相关的挫伤性胸段损伤后后肢关节运动学的恢复情况，人们了解甚少。一种新的功能评估工具——动态足部距离（DFD），被用于描述正常和受影响啮齿动物在整个步态周期中双脚之间的距离。本研究的目的是使用三维（3D）仪器化步态分析，评估和表征正常大鼠及T9挫伤损伤大鼠在跑步机运动过程中的DFD。尽管正常大鼠和受伤大鼠在第五跖骨头关节距离偏移方面表现出相似的模式，但我们发现脊髓损伤后在整个步态周期中双脚之间的距离明显更宽。这是第一项在实验室啮齿动物神经系统损伤后，量化整个步态周期中双脚之间的距离以及四肢之间进行的生物力学调整的研究。
