Department of Veterinary Sciences, University of Trás-os-Montes e Alto Douro, UTAD, Quinta de Prados, 5000-801 Vila Real, Portugal.
Department of Veterinary Sciences, University of Trás-os-Montes e Alto Douro, UTAD, Quinta de Prados, 5000-801 Vila Real, Portugal; CECAV, Centre for Animal Sciences and Veterinary Studies, University of Trás-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal.
Neurosci Biobehav Rev. 2019 Mar;98:18-28. doi: 10.1016/j.neubiorev.2018.12.027. Epub 2019 Jan 3.
The recovery of walking function following spinal cord injury (SCI) is of major importance to patients and clinicians. In experimental SCI studies, a rat model is widely used to assess walking function, following thoracic spinal cord lesion. In an effort to provide a resource which investigators can refer to when seeking the most appropriate functional assay, the authors have compiled and categorized the behavioral assessments used to measure the deficits and recovery of the gait in thoracic SCI rats. These categories include kinematic and kinetic measurements. Within this categorization, we discuss the advantages and disadvantages of each type of measurement. The present review includes the type of outcome data that they produce, the technical difficulty and the time required to potentially train the animals to perform them, and the need for expensive or highly specialized equipment. The use of multiple kinematic and kinetic parameters is recommended to identify subtle deficits and processes involved in the compensatory mechanisms of walking function after experimental thoracic SCI in rats.
脊髓损伤（SCI）后行走功能的恢复对患者和临床医生至关重要。在实验性 SCI 研究中，常采用大鼠模型来评估胸段脊髓损伤后行走功能。为了提供一个资源，供研究人员在寻求最合适的功能测定时参考，作者们对用于测量胸段 SCI 大鼠步态缺陷和恢复的行为评估进行了汇编和分类。这些类别包括运动学和动力学测量。在这一分类中，我们讨论了每种测量类型的优缺点。本综述包括它们产生的结果数据类型、技术难度、对动物进行潜在训练以进行这些测量所需的时间，以及对昂贵或高度专业化设备的需求。建议使用多个运动学和动力学参数来识别大鼠实验性胸段 SCI 后行走功能补偿机制中涉及的细微缺陷和过程。
