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Proc Natl Acad Sci U S A. 1979 Jun;76(6):2512-4. doi: 10.1073/pnas.76.6.2512.
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Biomolecular information analysis in neurotransmitter systems.神经递质系统中的生物分子信息分析
Acta Biotheor. 1984;33(1):3-33. doi: 10.1007/BF00045844.

本文引用的文献

1
Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units.多肽和蛋白质的立体化学标准。V. 三个相连肽单元系统的构象
Biopolymers. 1968 Oct;6(10):1425-36. doi: 10.1002/bip.1968.360061006.
2
Folding of polypeptide chains in proteins: a proposed mechanism for folding.蛋白质中多肽链的折叠：一种提出的折叠机制。
Proc Natl Acad Sci U S A. 1971 Sep;68(9):2293-7. doi: 10.1073/pnas.68.9.2293.
3
Nuclear magnetic resonance spectroscopy. Carbon-13 chemical shifts of small peptides as a function of pH.核磁共振光谱法。小肽的碳-13化学位移随pH值的变化情况。
J Am Chem Soc. 1972 Jun 28;94(13):4565-73. doi: 10.1021/ja00768a026.
4
Influence of local interactions on protein structure. I. Conformational energy studies of N-acetyl-N'-methylamides of Pro-X and X-Pro dipeptides.局部相互作用对蛋白质结构的影响。I. 脯氨酸-X和X-脯氨酸二肽的N-乙酰基-N'-甲基酰胺的构象能研究。
Biopolymers. 1977 Apr;16(4):811-43. doi: 10.1002/bip.1977.360160408.
5
Use of proton nuclear Overhauser effects for the determination of the conformations of amino acid residues in oligopeptides.利用质子核Overhauser效应确定寡肽中氨基酸残基的构象。
Biochem Biophys Res Commun. 1977 Mar 7;75(1):207-15. doi: 10.1016/0006-291x(77)91310-9.
6
Conformations of the repeat peptides of elastin in solution: an application of proton and carbon-13 magnetic resonance to the determination of polypeptide secondary structure.弹性蛋白重复肽段在溶液中的构象：质子和碳-13磁共振在多肽二级结构测定中的应用
CRC Crit Rev Biochem. 1976 Jun;4(1):1-45. doi: 10.3109/10409237609102557.
7
Identification of beta,beta-turns and unordered conformations in polypeptide chains by vacuum ultraviolet circular dichroism.利用真空紫外圆二色性鉴定多肽链中的β，β-转角和无序构象。
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3208-12. doi: 10.1073/pnas.74.8.3208.
8
Conformationally restricted bicyclic analogs of somatostatin.生长抑素的构象受限双环类似物。
Proc Natl Acad Sci U S A. 1978 Jun;75(6):2636-40. doi: 10.1073/pnas.75.6.2636.

β-转角的环化二肽模型

Cyclized dipeptide model for a beta-bend.

作者信息

Deslauriers R, Leach S J, Maxfield F R, Minasian E, McQuie J R, Meinwald Y C, Némethy G, Pottle M S, Rae I D, Scheraga H A, Stimson E R, Van Nispen J W

出版信息

Proc Natl Acad Sci U S A. 1979 Jun;76(6):2512-4. doi: 10.1073/pnas.76.6.2512.

DOI:10.1073/pnas.76.6.2512
PMID:288041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC383636/
Abstract

A cyclic dipeptide in which L-Ala-Gly was cyclized with epsilon-aminocaproic acid has been synthesized as a model for a beta-bend. Its conformational properties have been examined by means of conformational energy calculations and nuclear magnetic resonance, infrared, Raman, and circular dichroism spectroscopy in various solvents. These calculations and experiments suggest that a type II beta-bend exists in the Ala-Glymoiety, with an NH...O = C hydrogen bond in the epsilon-aminocaproic acid portion of the molecule, and that the molecule adopts a unique conformation in solution. In contrast, an open-chain analog of this compound exists in solution as an ensemble of conformations but with a significant amount of a type II beta-bend structure in the ensemble.

摘要

一种将L-丙氨酸-甘氨酸与ε-氨基己酸环化而成的环二肽已被合成出来，作为β-转角的模型。通过在各种溶剂中的构象能量计算以及核磁共振、红外、拉曼和圆二色光谱对其构象性质进行了研究。这些计算和实验表明，在丙氨酸-甘氨酸部分存在II型β-转角，在分子的ε-氨基己酸部分存在一个N-H...O = C氢键，并且该分子在溶液中呈现独特的构象。相比之下，该化合物的开链类似物在溶液中以构象集合体形式存在，但集合体中含有大量的II型β-转角结构。