Lund Harald, Pieber Melanie, Harris Robert A
Department of Clinical Neuroscience, Karolinska Institutet, Centre for Molecular Medicine, Karolinska Hospital at SolnaSolna, Sweden.
Front Aging Neurosci. 2017 Jul 28;9:234. doi: 10.3389/fnagi.2017.00234. eCollection 2017.
While bone marrow-derived Ly6C monocytes can infiltrate the central nervous system (CNS) they are developmentally and functionally distinct from resident microglia. Our understanding of the relative importance of these two populations in the distinct processes of pathogenesis and resolution of inflammation during neurodegenerative disorders was limited by a lack of tools to specifically manipulate each cell type. During recent years, the development of experimental cell-specific depletion models has enabled this issue to be addressed. Herein we compare and contrast the different depletion approaches that have been used, focusing on the respective functionalities of microglia and monocyte-derived macrophages in a range of neurodegenerative disease states, and discuss their prospects for immunotherapy.
虽然骨髓来源的Ly6C单核细胞可以浸润中枢神经系统（CNS），但它们在发育和功能上与常驻小胶质细胞不同。由于缺乏特异性操纵每种细胞类型的工具，我们对这两种细胞群在神经退行性疾病发病机制和炎症消退的不同过程中的相对重要性的理解受到限制。近年来，实验性细胞特异性耗竭模型的发展使得这个问题能够得到解决。在此，我们比较和对比了已使用的不同耗竭方法，重点关注小胶质细胞和单核细胞衍生的巨噬细胞在一系列神经退行性疾病状态下的各自功能，并讨论它们在免疫治疗中的前景。
