Yang Li, Zhang Yi
Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road, Zhengzhou, Henan Province 450052 China.
School of Life Sciences, Zhengzhou University, No.100 Kexue Road, Zhengzhou, Henan Province 450001 China.
Biomark Res. 2017 Aug 8;5:25. doi: 10.1186/s40364-017-0106-7. eCollection 2017.
The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now beginning to be elucidated. TAMs act as "protumoral macrophages", contributing to disease progression. As the relationship between TAMs and malignant tumors becomes clearer, TAMs are beginning to be seen as potential therapeutic targets in these cases. In this review, we will discuss how TAMs can be used as therapeutic targets of cancer in clinics.
长期以来，人们一直知道在肿瘤组织中可以发现包括巨噬细胞在内的各种免疫细胞。随着巨噬细胞可分化为经典激活或替代激活表型这一概念的引入，肿瘤相关巨噬细胞（TAM）的作用现在开始得到阐明。TAM作为“促肿瘤巨噬细胞”，促进疾病进展。随着TAM与恶性肿瘤之间的关系变得更加清晰，TAM在这些病例中开始被视为潜在的治疗靶点。在这篇综述中，我们将讨论TAM如何在临床上用作癌症的治疗靶点。
