Nakahira Mitsuhiko, Kuba Kiyomi, Matsumura Satoko, Sugasawa Masashi
Department of Head and Neck Surgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, Japan.
Case Rep Otolaryngol. 2017;2017:8143145. doi: 10.1155/2017/8143145. Epub 2017 Jul 19.
Two patients with primary small cell carcinoma (SmCC) of the hypopharynx, an extremely rare site for the occurrence of SmCC, are reported and nine additional well-documented cases are reviewed.
Case report and review of the literature concerning primary SmCC of the hypopharynx.
On the final analysis, we reviewed eleven cases of primary SmCC of the hypopharynx. The tumors contained mixed elements of SmCC and squamous cell carcinoma (SCC) in six (55%) of eleven patients. Out of eleven patients, two patients had distant metastasis at the initial presentation. Even though nine patients presented with locoregional disease, development of distant metastasis after treatment was seen in five patients (56%), whereas there was no report of treatment failure on the primary site. To achieve more than two-year survival, patients should have received more than 4 cycles of chemotherapy.
We report two cases of primary SmCC of the hypopharynx with a review of the literature. In more than half of the cases, combined carcinomas with SCC are seen. Because this tumor has a strong propensity for distant metastasis even in patients with clinically localized tumor, new powerful systemic agents should be explored.
报告2例下咽原发性小细胞癌（SmCC），下咽是SmCC极为罕见的发病部位，并复习另外9例有充分文献记载的病例。
病例报告及关于下咽原发性SmCC的文献复习。
最终分析时，我们复习了11例下咽原发性SmCC病例。11例患者中有6例（55%）肿瘤包含SmCC和鳞状细胞癌（SCC）的混合成分。11例患者中，2例初诊时即有远处转移。尽管9例患者表现为局部区域疾病，但治疗后仍有5例（56%）出现远处转移，而原发部位未报告治疗失败情况。为实现超过两年的生存，患者应接受超过4个周期的化疗。
我们报告2例下咽原发性SmCC并复习文献。超过半数病例可见与SCC的联合癌。由于该肿瘤即使在临床局限性肿瘤患者中也有很强的远处转移倾向，应探索新的强效全身治疗药物。
