Uwa Nobuhiro, Terada Tomonori, Mohri Takeshi, Okazaki Ken, Tsukamoto Yoshitane, Hirota Seiichi, Sakagami Masafumi
Department of Otolaryngology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, Japan.
Auris Nasus Larynx. 2013 Feb;40(1):106-9. doi: 10.1016/j.anl.2012.01.006. Epub 2012 Feb 10.
We report an extremely rare case of combined small cell carcinoma (combined SmCC) of the hypopharynx. A 73-year-old male presented with multiple left neck swellings for 1 month. A tumorous lesion was found in the left pyriform sinus, and biopsy revealed that the lesion was squamous cell carcinoma (SqCC). Surgery was performed and pathological examination led to a diagnosis as combined SmCC, composed of SqCC and small cell carcinoma (SmCC). One month after surgery, a contrast-CT indicated metastases to the cervical lymph node (LN), mediastinum and liver. We performed 5 courses of chemotherapy with the use of cisplatin (CDDP) and irinotecan (CPT-11). The patient temporarily showed a favorable response to the chemotherapy; however, eventually he died of regrowth of the tumor. Combined SmCC is a disease with a poor prognosis. Although biopsy sometimes fails to detect the SmCC component, intensive diagnosis and treatment are necessary.
我们报告了1例极其罕见的下咽联合小细胞癌（combined SmCC）病例。一名73岁男性因左侧颈部多处肿胀1个月就诊。在左侧梨状窦发现一个肿瘤性病变，活检显示该病变为鳞状细胞癌（SqCC）。进行了手术，病理检查诊断为combined SmCC，由SqCC和小细胞癌（SmCC）组成。术后1个月，增强CT显示颈部淋巴结（LN）、纵隔和肝脏转移。我们使用顺铂（CDDP）和伊立替康（CPT-11）进行了5个疗程的化疗。患者对化疗暂时显示出良好反应；然而，最终他死于肿瘤复发。Combined SmCC是一种预后较差的疾病。尽管活检有时未能检测到SmCC成分，但仍需要进行强化诊断和治疗。
