Han Dong-Ji, He Zhi-Gang, Zhou Zhi-Qiang, Feng Li, Liu Cheng, Xiang Yan, Xiang Hong-Bing
Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, Hubei, China.
Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, Hubei, China.
Am J Neurodegener Dis. 2017 Jul 25;6(3):26-31. eCollection 2017.
A 56-year-old epileptic patient underwent right hemicolectomy and cholecystectomy surgery under general endotracheal anesthesia. Anesthesia was maintained with sevoflurane, and sufentanil, rocuronium, and dexmedetomidine infusions. After the operation and confirmation of neuromuscular recovery, the patient woke from anesthesia within 15 min and successfully extubated. After the vital signs of patient were stable, the patient was transported to post anesthesia care unit (PACU). 6 h after the surgery, he fell into a stuporous state for lasting 14 h and EEG showed no epileptiform discharges. Stupor did re-occur in 2 days after operation. 36 hours after operation, all signs of the stuporous state resolved spontaneously. Apparent dexmedetomidine-induced stuporous state has not been reported in the human literature.
一名56岁的癫痫患者在全身气管内麻醉下接受了右半结肠切除术和胆囊切除术。麻醉维持采用七氟烷，并输注舒芬太尼、罗库溴铵和右美托咪定。手术结束并确认神经肌肉恢复后，患者在15分钟内从麻醉中苏醒并成功拔管。患者生命体征稳定后，被转运至麻醉后监护病房（PACU）。术后6小时，患者陷入昏迷状态，持续14小时，脑电图显示无癫痫样放电。术后2天昏迷再次出现。术后36小时，昏迷状态的所有体征均自发消失。右美托咪定引起明显昏迷状态在人类文献中尚未见报道。
