Kershaw Geoffrey
Institute of Haematology, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW, 2050, Australia.
Methods Mol Biol. 2017;1646:75-83. doi: 10.1007/978-1-4939-7196-1_5.
The activated partial thromboplastin time (APTT) is a useful global assay for the assessment of the contact factor pathway of hemostasis and its inhibitors. The test is usually performed on fully automated analyzers using commercially prepared reagents. The three main clinical areas of interest are detection of factor deficiencies, detection of lupus anticoagulants and in the monitoring of therapy with unfractionated heparin. Methods are described here for assessing APTT reagents for their sensitivity to clotting time prolongation in each of these areas of interest.
活化部分凝血活酶时间（APTT）是评估止血接触因子途径及其抑制剂的一种有用的全面检测方法。该检测通常使用商业制备的试剂在全自动分析仪上进行。三个主要关注的临床领域是凝血因子缺乏的检测、狼疮抗凝物的检测以及普通肝素治疗的监测。本文介绍了评估APTT试剂在这些关注领域中对凝血时间延长敏感性的方法。
