Undas Anetta
Institute of Cardiology, Jagiellonian University Medical College, 80 Pradnicka Street, 31-202, Cracow, Poland.
Methods Mol Biol. 2017;1646:105-110. doi: 10.1007/978-1-4939-7196-1_8.
Fibrinogen is measured in plasma most commonly using the Clauss method, based on the comparison of thrombin clotting times of dilutions of plasma against a plasma standard. Thrombin time (TT) is a coagulation assay, which reflects the conversion of fibrinogen to fibrin after addition of thrombin reagent. Measurement of clottable fibrinogen and TT allows detecting inborn (congenital) and acquired qualitative and quantitative disorders of fibrinogen that can lead to thrombotic or bleeding events.
纤维蛋白原通常在血浆中采用克劳斯法进行测定，该方法基于将血浆稀释液的凝血酶凝血时间与血浆标准品进行比较。凝血酶时间（TT）是一种凝血检测方法，它反映了加入凝血酶试剂后纤维蛋白原向纤维蛋白的转化。可凝固纤维蛋白原和TT的测定有助于检测可能导致血栓形成或出血事件的先天性（遗传性）和后天性纤维蛋白原定性及定量异常。
