Rhone Erika T, Carmody J Bryan
Division of Nephrology, Department of Pediatrics, University of Virginia Children's Hospital, Charlottesville, Virginia, USA.
Division of Nephrology, Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, USA.
Pediatr Int. 2017 Aug;59(8):948-950. doi: 10.1111/ped.13328.
Elevated serum uric acid is associated with hypertension and chronic kidney disease. We evaluated the relationship between birthweight and uric acid in a nationally representative sample of 5390 US adolescents aged 12-15 in the National Health and Nutrition Examination Survey from 1999 to 2012. There was an inverse association between birthweight and uric acid after adjustment for sex, age, race, obesity, and dietary sodium intake. Each 1 kg increase in birthweight was associated with decreased uric acid by 0.11 mg/dL (95% CI: -0.16 to -0.06; model R = 0.32). This relationship was stronger in adolescents with elevated blood pressure (β = -0.25; 95% CI: -0.44 to -0.06; R = 0.50) but persisted in adolescents with normal blood pressure (β = -0.10; 95% CI: -0.15 to -0.05; R = 0.31). In conclusion, lower birthweight is associated with higher uric acid in US adolescents. These findings may support the hypothesis that reduced nephron number is associated with elevated uric acid.
血清尿酸水平升高与高血压和慢性肾脏病相关。我们在1999年至2012年美国国家健康与营养检查调查中，对5390名12至15岁具有全国代表性的美国青少年样本进行了出生体重与尿酸之间关系的评估。在对性别、年龄、种族、肥胖和饮食钠摄入量进行校正后，出生体重与尿酸之间呈负相关。出生体重每增加1千克，尿酸水平降低0.11毫克/分升（95%置信区间：-0.16至-0.06；模型R = 0.32）。这种关系在血压升高的青少年中更强（β = -0.25；95%置信区间：-0.44至-0.06；R = 0.50），但在血压正常的青少年中也持续存在（β = -0.10；95%置信区间：-0.15至-0.05；R = 0.31）。总之，在美国青少年中，较低的出生体重与较高的尿酸水平相关。这些发现可能支持肾单位数量减少与尿酸水平升高相关的假说。
