Keio University Health Center, Yokohama-shi, Japan.
Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan.
PLoS One. 2020 Nov 17;15(11):e0242272. doi: 10.1371/journal.pone.0242272. eCollection 2020.
Laboratory tests of adolescents are often interpreted by using reference intervals derived from adults, even though these populations differ in their physical and physiologic characteristics and disease susceptibility. Therefore, to examine the distribution of laboratory values specific for adolescents, we analyzed hematologic and biochemical measurements obtained from 12,023 healthy Japanese adolescents (ages 15 through 18 years; male, 9165; female, 2858) during 2009 through 2018. Distributions were shown as medians with 95% (2.5th and 97.5th percentiles) of values and were compared with those from previous studies that examined similar Asian populations. There were some differences between hematologic parameters, serum creatinine and uric acid concentration, and lipid levels of Japanese adults and adolescents. In comparison with other Asian populations, the distributions of serum uric acid and high-density-lipoprotein cholesterol in the present study were slightly higher than those in the other studies. Although further research is need, the distributions of hematologic and biochemical tests in adolescents may have the potential to facilitate the early identification and management of disease in this population.
实验室检测结果通常使用从成年人中得出的参考区间来解释，即使这两个群体在身体和生理特征以及疾病易感性方面存在差异。因此，为了研究青少年特有的实验室值的分布情况，我们分析了 2009 年至 2018 年间 12023 名健康日本青少年（年龄 15 至 18 岁；男性 9165 名，女性 2858 名）的血液学和生化测量值。分布情况以中位数表示，范围为 95%（2.5%和 97.5%分位数），并与之前研究类似亚洲人群的研究结果进行了比较。血液学参数、血清肌酐和尿酸浓度以及脂质水平在日本成年人和青少年之间存在一些差异。与其他亚洲人群相比，本研究中血清尿酸和高密度脂蛋白胆固醇的分布略高于其他研究。尽管需要进一步研究，但青少年血液学和生化检测的分布可能有助于早期识别和管理该人群的疾病。
