Kohdaira T, Kinoshita Y, Konno M, Oshima H
Andrologia. 1986 Nov-Dec;18(6):610-7. doi: 10.1111/j.1439-0272.1986.tb01839.x.
The present study is designed to investigate localization of gamma-glutamyl transpeptidase (gamma-GTP) in male reproductive organs and its age-related changes using Wistar rats aged 2 to 15 weeks. Histochemically, gamma-GTP activity was detected intensively in epithelial cells of epididymides and seminal vesicles and weakly in those of anterior prostates, but not in testes under the present conditions. Biochemically, the highest gamma-GTP activity was found in epididymal head portions. The order of the activity was epididymides (head greater than body greater than tail), seminal vesicles, prostates and testes. The activity increases with sexual maturation in epididymides and seminal vesicles, but not in prostates. Since gamma-GTP is an enzyme involved in the incorporation of amino acids, the present findings suggest that not only epididymides but also seminal vesicles possess uptake mechanisms for amino acids.
本研究旨在利用2至15周龄的Wistar大鼠，研究γ-谷氨酰转肽酶（γ-GTP）在雄性生殖器官中的定位及其与年龄相关的变化。组织化学研究发现，在当前条件下，附睾和精囊的上皮细胞中γ-GTP活性较强，前前列腺的上皮细胞中γ-GTP活性较弱，而睾丸中未检测到γ-GTP活性。生化研究发现，附睾头部γ-GTP活性最高。活性顺序为附睾（头部＞体部＞尾部）、精囊、前列腺和睾丸。附睾和精囊中的活性随性成熟而增加，而前列腺中则不然。由于γ-GTP是一种参与氨基酸掺入的酶，目前的研究结果表明，不仅附睾而且精囊都具有氨基酸摄取机制。
