Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore.
Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12723-12726. doi: 10.1002/anie.201707134. Epub 2017 Aug 30.
A nickel-catalyzed asymmetric reductive Heck reaction of aryl chlorides has been developed that affords substituted indolines with high enantioselectivity. Manganese powder is used as the terminal reductant with water as a proton source. Mechanistically, it is distinct from the palladium-catalyzed process in that the nickel-carbon bond is converted into a C-H bond to release the product through protonation instead of hydride donation followed by C-H reductive elimination on Pd.
发展了一种镍催化的不对称还原 Heck 反应，可用于芳基氯的反应，以高对映选择性得到取代的吲哚啉。该反应以锰粉作为末端还原剂，以水作为质子源。在机理上，它与钯催化过程不同，因为镍-碳键被转化为 C-H 键，通过质子化释放产物，而不是钯催化过程中的氢化物供体，然后通过 C-H 还原消除。
