Gibbs W N, Lofters W S, Campbell M, Hanchard B, LaGrenade L, Cranston B, Hendriks J, Jaffe E S, Saxinger C, Robert-Guroff M
Ann Intern Med. 1987 Mar;106(3):361-8. doi: 10.7326/0003-4819-106-3-361.
Of 95 patients consecutively diagnosed with non-Hodgkin lymphoma, 52 (55%) had antibodies to human T-cell leukemia-lymphoma virus, type I. Antibody positivity was strongly associated with skin involvement, leukemia, and hypercalcemia (p less than 0.02). Two patients had systemic opportunistic infections. Neither meningeal nor lung infiltration was detected, and lymph node infiltration was diffuse in all patients. Of 36 patients who received immunophenotypic classifications, 30 had diseases that affected the T-cell system, and the cells of all tested patients with these diseases showed the helper/inducer (T4) phenotype. Twenty-seven of these thirty-six patients were found to have adult T-cell leukemia-lymphoma, and of the 27, 24 had antibodies to HTLV-I. The median duration of survival in patients with adult T-cell leukemia-lymphoma was 17 weeks, but a subgroup of 9 patients had indolent courses and a median survival of 81 weeks, which suggests that the disease has differing expression with courses that range from smoldering and indolent to acute and rapidly fatal. Hypercalcemia was the most important prognostic determinant of adult T-cell leukemia-lymphoma.
在连续诊断的95例非霍奇金淋巴瘤患者中，52例（55%）有抗I型人类T细胞白血病-淋巴瘤病毒抗体。抗体阳性与皮肤受累、白血病和高钙血症密切相关（p<0.02）。2例患者发生全身性机会性感染。未检测到脑膜或肺部浸润，所有患者均有弥漫性淋巴结浸润。在36例接受免疫表型分类的患者中，30例患有影响T细胞系统的疾病，所有检测的患有这些疾病的患者细胞均表现为辅助/诱导（T4）表型。这36例患者中有27例被发现患有成人T细胞白血病-淋巴瘤，其中27例中有24例有抗HTLV-I抗体。成人T细胞白血病-淋巴瘤患者的中位生存期为17周，但9例患者病程缓慢，中位生存期为81周，这表明该疾病有不同的表现形式，病程从隐匿性和缓慢到急性和快速致命不等。高钙血症是成人T细胞白血病-淋巴瘤最重要的预后决定因素。
