Kwei Kimberly, Frucht Steven
Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Int Rev Neurobiol. 2017;134:973-986. doi: 10.1016/bs.irn.2017.06.002. Epub 2017 Jul 10.
There are a few syndromes involving the nonmotor symptoms of Parkinson's disease and other movement disorders that can quickly lead to severe morbidity and mortality, and, as such, need rapid identification and management. Among these are neuroleptic malignant syndrome, serotonin syndrome, dopamine agonist withdrawal syndrome, and dystonic storm. It is important to maintain a high index of suspicion for these disorders as lack of identification can lead to death. Many of these acutely occurring nonmotor syndromes are primarily the result of imbalances in dopaminergic and serotonergic systems due to changes in pharmacologic management of psychiatric disorders or Parkinson's disease. We discuss these acutely occurring nonmotor symptoms in order to raise awareness and also to highlight how these extremes in symptoms may uniquely shed light on the pathophysiology of Parkinson's disease.
有几种涉及帕金森病和其他运动障碍非运动症状的综合征，可迅速导致严重发病和死亡，因此需要快速识别和处理。其中包括抗精神病药恶性综合征、5-羟色胺综合征、多巴胺激动剂撤药综合征和张力障碍风暴。对这些疾病保持高度怀疑指数很重要，因为无法识别可能导致死亡。这些急性发生的非运动综合征大多主要是由于精神疾病或帕金森病药物治疗改变导致多巴胺能和5-羟色胺能系统失衡所致。我们讨论这些急性发生的非运动症状，以提高认识，并强调这些极端症状如何可能独特地揭示帕金森病的病理生理学。
