花生四烯酸是G酸平滑肌收缩活性的原因。
Arachidonic acid is responsible for the smooth muscle-contracting activity of G-acid.
作者信息
Bates H A, Sih C J
出版信息
Proc Natl Acad Sci U S A. 1979 Jun;76(6):2712-4. doi: 10.1073/pnas.76.6.2712.
Abstract
G-acid, a smooth-muscle-contracting substance isolated from human blood plasma, was previously identified as 3-octadecenoic acid. Synthetic cis- and trans-3-octadecenoic acid, however, are biologically inactive. G-acid actually consists of a mixture of fatty acids, characteristic of animal tissues. The biological activity is caused by arachidonic acid, which contracts smooth muscle upon in situ conversion to prostaglandins.
摘要
G酸是一种从人血浆中分离出的能使平滑肌收缩的物质，先前被鉴定为3-十八碳烯酸。然而，合成的顺式和反式3-十八碳烯酸没有生物活性。G酸实际上是一种脂肪酸混合物，具有动物组织的特征。其生物活性是由花生四烯酸引起的，花生四烯酸在原位转化为前列腺素时会使平滑肌收缩。
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