狗离体后肢对花生四烯酸的血管收缩反应。
Vasoconstrictor response to arachidonic acid in the isolated hind limb of the dog.
作者信息
Fitzpatrick T M, Johnson M, Kot P A, Ramwell P W, Rose J C
出版信息
Br J Pharmacol. 1977 Feb;59(2):269-73. doi: 10.1111/j.1476-5381.1977.tb07489.x.
Abstract
1 Arachidonic acid(AA) (25-200 mug/kg) produced a dose-related increase in perfusion pressure in dog isolated hind limbs perfused with either blood or a platelet-free perfusate. 2 Prostaglandin E2 produced vasodilation while prostaglandin F2 alpha produced no vascular change at these administered doses. 3 Phentolamine did not alter the arachidonic acid response, eliminating possible alpha-adrenoceptor mediation. 4 Aspirin and idomethacin blocked the vasoconstrictor response to AA. 5 This study indicates that a vasoactive intermediate in prostaglandin synthesis can be elaborated in the absence of platelets.
摘要
- 花生四烯酸（AA）（25 - 200微克/千克）使灌注血液或无血小板灌注液的犬离体后肢灌注压呈剂量依赖性升高。2. 前列腺素E2引起血管舒张，而在这些给药剂量下前列腺素F2α未引起血管变化。3. 酚妥拉明未改变花生四烯酸的反应，排除了可能的α - 肾上腺素能受体介导作用。4. 阿司匹林和吲哚美辛阻断了对AA的血管收缩反应。5. 本研究表明，在无血小板的情况下可产生前列腺素合成中的血管活性中间体。
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