Doiuchi J, Hamada M, Ito T, Kokubu T
Clin Cardiol. 1987 Jan;10(1):26-30. doi: 10.1002/clc.4960100106.
To compare the effects of calcium-channel blockers with those of beta-adrenergic blockers in patients with hypertrophic cardiomyopathy (HCM), diastolic time intervals (IIA-O time, from the second heart sound to the O point of apexcardiogram, IIA-MVO time, from IIA to the mitral valve opening, and MVO-O time, from the MVO to the O point of apexcardiogram), and A-wave ratio measured from apexcardiogram were evaluated before and after more than three months of treatment. In both groups, heart rate significantly decreased after treatment. The IIA-MVO time was not affected by either drug. The IIA-O and the MVO-O times were significantly shortened by calcium-channel blockers (from 234.6 +/- 77.4 ms to 204.6 +/- 39.2 ms; p less than 0.01, and from 133.1 +/- 66.4 ms to 100.3 +/- 34.0 ms; p less than 0.01, respectively). However, they were not affected by beta-adrenergic blocker. A-wave ratio significantly decreased after calcium-channel blockers (from 18.0 +/- 9.8% to 13.7 +/- 7.3%; p less than 0.01) and beta-adrenergic blocker (from 21.7 +/- 12.6% to 17.2 +/- 8.0%; p less than 0.01). From these observations, it is suggested tht calcium-channel blockers improved the early diastolic filling rate, whereas beta-adrenergic blocker did not affect it. It is concluded that the effects of calcium-channel blockers and beta-adrengergic blocker on early diastolic time intervals were different in patients with HCM.
为比较钙通道阻滞剂与β-肾上腺素能阻滞剂对肥厚型心肌病（HCM）患者的疗效，在治疗三个多月前后，对舒张期时间间期（IIA-O时间，从第二心音到心尖搏动图的O点；IIA-MVO时间，从IIA到二尖瓣开放；MVO-O时间，从二尖瓣开放到心尖搏动图的O点）以及从心尖搏动图测量的A波比率进行了评估。两组患者治疗后心率均显著降低。IIA-MVO时间不受任何一种药物的影响。钙通道阻滞剂使IIA-O和MVO-O时间显著缩短（分别从234.6±77.4毫秒缩短至204.6±39.2毫秒；p<0.01，以及从133.1±66.4毫秒缩短至100.3±34.0毫秒；p<0.01）。然而，它们不受β-肾上腺素能阻滞剂的影响。钙通道阻滞剂（从18.0±9.8%降至13.7±7.3%；p<0.01）和β-肾上腺素能阻滞剂（从21.7±12.6%降至17.2±8.0%；p<0.01）治疗后A波比率均显著降低。从这些观察结果来看，提示钙通道阻滞剂改善了舒张早期充盈率，而β-肾上腺素能阻滞剂对此无影响。结论是，钙通道阻滞剂和β-肾上腺素能阻滞剂对HCM患者舒张早期时间间期的影响不同。
