Hamada M, Matsuzaki K, Kazatani Y, Shigematsu Y, Sekiya M, Ochi T, Ito T, Kokubu T
Jpn Circ J. 1985 Mar;49(3):267-75. doi: 10.1253/jcj.49.267.
To investigate the qualitative difference in myocardial hypertrophy that exists between hypertrophic cardiomyopathy (HCM) and essential hypertension (HT), we measured the mean wall thickness (MWT), the early diastolic time intervals (IIA-MVO time: from the second heart sound to the point of mitral valve opening, MVO-O time: from MVO to the O point of apexcardiogram) and the MVO-O/IIA-MVO ratio. The MWT in HCM and HT was measured by biventriculogram and echocardiogram, respectively. The MWT showed no significant difference between HT (13.1 +/- 3.0 mm) and non-obstructive type of HCM (14.8 +/- 3.7), but the MWT in obstructive type (1.08 +/- 0.24) was significantly thinner than that in HT. As the MWT increased, both IIA-MVO and MVO-O time were prolonged in both groups. But the mode of prolongation was quite different. In HT, the prolongation of the IIA-MVO time was almost always greater than that of the MVO-O time. In HCM, the prolongation of the latter was greater than that of the former. The MVO-O/IIA-MVO ratio in HT was significantly less than that in normal subjects, but those in HCM were significantly greater. These findings suggest that the differences in the early diastolic time intervals between HCM and HT are not due to the magnitude of the left ventricular hypertrophy, but due to myocardial characteristics.
为研究肥厚型心肌病（HCM）和原发性高血压（HT）之间存在的心肌肥厚的质的差异，我们测量了平均壁厚度（MWT）、舒张早期时间间期（IIA-MVO时间：从第二心音到二尖瓣开放点，MVO-O时间：从MVO到心尖搏动图的O点）以及MVO-O/IIA-MVO比值。HCM和HT的MWT分别通过双心室造影和超声心动图测量。HT（13.1±3.0mm）和非梗阻型HCM（14.8±3.7）之间的MWT无显著差异，但梗阻型的MWT（1.08±0.24）明显薄于HT。随着MWT增加，两组的IIA-MVO和MVO-O时间均延长。但延长方式截然不同。在HT中，IIA-MVO时间的延长几乎总是大于MVO-O时间的延长。在HCM中，后者的延长大于前者。HT的MVO-O/IIA-MVO比值显著低于正常受试者，但HCM中的该比值显著更高。这些发现表明，HCM和HT舒张早期时间间期的差异不是由于左心室肥厚的程度，而是由于心肌特性。
