Grotegut Chad A, Lewis Lauren L, Manuck Tracy A, Allen Terrence K, James Andra H, Seco Aurelien, Deneux-Tharaux Catherine
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Am J Perinatol. 2018 Jan;35(1):78-83. doi: 10.1055/s-0037-1606119. Epub 2017 Aug 14.
Total dose of oxytocin received during labor is an important variable in studies of human labor but is difficult to calculate. We sought to identify a surrogate measure for total dose of oxytocin received.
For each subject receiving oxytocin during labor, the oxytocin total dose received in labor was calculated as the area under the curve. Maximal oxytocin infusion rate, total duration of oxytocin infusion, and the product of both, defined as the oxytocin product, were then each correlated with the total dose of oxytocin received using the Pearson's correlation coefficient.
Oxytocin dosing data were available from 402 women at Duke and 6,907 women from Pithagore6. The two variables alone, or combined as the oxytocin product, demonstrated a high correlation with the oxytocin total dose ( > 0.7), with the oxytocin product demonstrating the highest ( > 0.9). This was true whether labor was induced or augmented and whether delivery was vaginal or cesarean.
The oxytocin product, composed of two easily obtained variables, demonstrated a very high correlation with total oxytocin dose received in labor and represents a simple and accurate surrogate for total dose of oxytocin received during labor. The oxytocin product can be used in clinical studies in which oxytocin dose is an important variable.
分娩期间接受的缩宫素总剂量是人类分娩研究中的一个重要变量，但难以计算。我们试图确定一种替代指标来衡量所接受的缩宫素总剂量。
对于每一位在分娩期间接受缩宫素的受试者，将分娩期间接受的缩宫素总剂量计算为曲线下面积。然后，使用Pearson相关系数，将最大缩宫素输注速率、缩宫素输注总时长以及两者的乘积（定义为缩宫素乘积）分别与所接受的缩宫素总剂量进行相关性分析。
杜克大学有402名女性以及来自Pithagore6的6907名女性的缩宫素给药数据。单独的这两个变量，或合并为缩宫素乘积，均与缩宫素总剂量呈现高度相关性（>0.7），其中缩宫素乘积的相关性最高（>0.9）。无论分娩是引产还是催产，以及分娩方式是阴道分娩还是剖宫产，情况均如此。
由两个易于获取的变量组成的缩宫素乘积，与分娩期间所接受的缩宫素总剂量呈现出非常高的相关性，代表了分娩期间所接受缩宫素总剂量的一种简单而准确的替代指标。缩宫素乘积可用于缩宫素剂量是重要变量的临床研究。
