Hadj Ahmed Samia, Kaoubaa Nadia, Kharroubi Wafa, Zarrouk Amira, Najjar Mohamed Fadhel, Batbout Fathi, Gamra Habib, Lizard Gerard, Hammami Mohamed
Faculty of Medicine, Research Laboratory LR12ES05, Lab-NAFS 'Nutrition - Functional Food & Vascular Health', University of Monastir (Tunisia), Avicene st, 5019, Monastir, Tunisia.
Biochemistry Department CHU Fattouma Bourguiba Monastir- Tunisia, Monastir, Tunisia.
Lipids Health Dis. 2017 Aug 14;16(1):154. doi: 10.1186/s12944-017-0538-y.
Some factors related to diet are known to be involved in the progression of atherosclerosis in humans.
The relationship between plasma fatty acid (FA) levels and the severity of coronary artery disease (CAD), evaluated by Gensini score (GS), was investigated in CAD Tunisian patients compared to controls. Lipid profiles were analyzed, GS was calculated in CAD and non-CAD patients and compared to controls.
CAD patients showed an alteration of conventional lipid parameters. In fact, a significant increase of plasmatic triglycerides (TG) level, atherogenic lipid ratios (TC/HDL-C,TG/HDL-C, LDL-C/HDL-C); and ApoB/ApoA1 was observed in the CAD group comparatively to controls (p < 0.001). Gensini score was showed to be a good indicator to evaluate cholesterol metabolism disorders associated with HDL-C since a negative association was found between HDL-C levels and GS for the two groups of patients. In addition, in the relation with FA and classes of FA, a negative association was found as expected, between Gensini score and total MUFA, PUFA n-3, total PUFA, GLA, DGLA and DHA. Furthermore, a positive association with stearic and erucic acid was found. Suggests that, GS is also a good indicator to evaluate FA metabolic disorders. Higher elongation index and modifications of desaturation index (D5D, D6D and D9D) were observed in patients compared to controls, supporting FA metabolism modifications.
In conclusion, although that Tunisian population appears to follow the Mediterranean diet, variations of plasmatic FA levels and desaturase activities in CAD patients highlights an alteration of FA metabolism and suggests an important implication of certain FA in the development of atherosclerosis.
已知一些与饮食相关的因素参与人类动脉粥样硬化的进展。
在突尼斯冠心病患者与对照组中，研究血浆脂肪酸（FA）水平与通过Gensini评分（GS）评估的冠状动脉疾病（CAD）严重程度之间的关系。分析血脂谱，计算CAD患者和非CAD患者的GS并与对照组进行比较。
CAD患者显示传统脂质参数发生改变。事实上，与对照组相比，CAD组血浆甘油三酯（TG）水平、致动脉粥样硬化脂质比率（TC/HDL-C、TG/HDL-C、LDL-C/HDL-C）以及载脂蛋白B/载脂蛋白A1显著升高（p < 0.001）。Gensini评分被证明是评估与HDL-C相关的胆固醇代谢紊乱的良好指标，因为在两组患者中HDL-C水平与GS之间存在负相关。此外，在与FA及其类别关系方面，正如预期的那样，Gensini评分与总单不饱和脂肪酸、多不饱和脂肪酸n-3、总多不饱和脂肪酸、γ-亚麻酸、二高γ-亚麻酸和二十二碳六烯酸之间存在负相关。此外，还发现与硬脂酸和芥酸呈正相关。这表明，GS也是评估FA代谢紊乱的良好指标。与对照组相比，患者中观察到更高的延伸指数以及去饱和指数（D5D、D6D和D9D）的改变，支持FA代谢的改变。
总之，尽管突尼斯人群似乎遵循地中海饮食，但CAD患者血浆FA水平和去饱和酶活性的变化突出了FA代谢的改变，并表明某些FA在动脉粥样硬化发展中具有重要影响。
