Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
Kidney Int. 2017 Sep;92(3):553-555. doi: 10.1016/j.kint.2017.04.041.
The prerequisite for successful treatment is an accurate diagnosis, a concept coined precision medicine. Progression of interstitial fibrosis and tubular atrophy is widely considered the natural course for all transplanted kidneys. In this issue, Gosset et al. describe discrete disease entities in individual patients and their contribution to interstitial fibrosis and tubular atrophy and its progression. This represents a major step forward in stratifying patients for targeted treatment trials (i.e., a step toward precision medicine in renal transplantation).
成功治疗的前提是准确的诊断，这一概念被称为精准医学。间质纤维化和肾小管萎缩的进展被广泛认为是所有移植肾脏的自然病程。在本期杂志中，Gosset 等人描述了个别患者中的离散疾病实体及其对间质纤维化和肾小管萎缩及其进展的贡献。这是朝着为靶向治疗试验分层患者（即朝着肾移植的精准医学迈进的一步）迈出的重要一步。
