基于多位点可变数目串联重复序列分析（MLVA）分型的法国027型艰难梭菌菌株的时空变异性
Spatio-temporal variability of the epidemic 027 Clostridium difficile strains in France based on MLVA typing.
作者信息
Couturier Jeanne, Eckert Catherine, Barbut Frédéric
机构信息
National Reference Laboratory for C. difficile, Hôpital Saint-Antoine, 34 rue Crozatier, 75012 Paris, France; Université Paris Descartes, Faculté de Pharmacie, EA4065, 4 Avenue de l'Observatoire, 75006 Paris, France.
National Reference Laboratory for C. difficile, Hôpital Saint-Antoine, 34 rue Crozatier, 75012 Paris, France.
出版信息
Anaerobe. 2017 Dec;48:179-183. doi: 10.1016/j.anaerobe.2017.08.007. Epub 2017 Aug 12.
MLVA analysis of 103 PCR ribotype 027 strains showed a regional specificity and the persistence of the same clone within a hospital several years apart. Capillary electrophoresis PCR ribotyping led to the identification of seven 027 variant strains and five 176 strains, four of them being implicated in an outbreak.
对103株PCR核糖体分型027菌株进行的多位点可变数目串联重复序列分析显示出区域特异性，并且同一克隆在相隔数年的同一家医院内持续存在。毛细管电泳PCR核糖体分型鉴定出7株027变异菌株和5株176菌株，其中4株与一次暴发有关。
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